New Blocking Antibodies Impede Adhesion, Migration and Survival of Ovarian Cancer Cells, Highlighting MFGE8 as a Potential Therapeutic Target of Human Ovarian Carcinoma

Milk Fat Globule – EGF – factor VIII (MFGE8), also called lactadherin, is a secreted protein, which binds extracellularly to phosphatidylserine and to αvβ3 and αvβ5 integrins. On human and mouse cells expressing these integrins, such as endothelial cells, phagocytes and some tumors, MFGE8/lactadheri...

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Detalles Bibliográficos
Autores principales: Tibaldi, Lorenzo, Leyman, Shirley, Nicolas, André, Notebaert, Sofie, Dewulf, Melissa, Ngo, Thu Hoa, Zuany-Amorim, Claudia, Amzallag, Nathalie, Bernard-Pierrot, Isabelle, Sastre-Garau, Xavier, Théry, Clotilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745384/
https://www.ncbi.nlm.nih.gov/pubmed/23977342
http://dx.doi.org/10.1371/journal.pone.0072708

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