Ablation of RIC8A Function in Mouse Neurons Leads to a Severe Neuromuscular Phenotype and Postnatal Death

Resistance to inhibitors of cholinesterase 8 (RIC8) is a guanine nucleotide exchange factor required for the intracellular regulation of G protein signalling. RIC8 activates different Gα subunits via non-canonical pathway, thereby amplifying and prolonging the G protein mediated signal. In order to...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruisu, Katrin, Kask, Keiu, Meier, Riho, Saare, Merly, Raid, Raivo, Veraksitš, Alar, Karis, Alar, Tõnissoo, Tambet, Pooga, Margus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745415/
https://www.ncbi.nlm.nih.gov/pubmed/23977396
http://dx.doi.org/10.1371/journal.pone.0074031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745415/
https://www.ncbi.nlm.nih.gov/pubmed/23977396
http://dx.doi.org/10.1371/journal.pone.0074031

Ejemplares similares