A functional link between FOXA1 and breast cancer SNPs

Genome-wide association studies have revealed a multitude of breast cancer-associated SNPs. The majority of these SNPs are located in noncoding regions of the genome. Yet how they contribute to breast cancer development is unknown. Recently, a groundbreaking study by the Lupien group has shown that...

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Detalles Bibliográficos
Autores principales: Katika, Madhumohan R, Hurtado, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745646/
https://www.ncbi.nlm.nih.gov/pubmed/23427833
http://dx.doi.org/10.1186/bcr3360
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author Katika, Madhumohan R
Hurtado, Antoni
author_facet Katika, Madhumohan R
Hurtado, Antoni
author_sort Katika, Madhumohan R
collection PubMed
description Genome-wide association studies have revealed a multitude of breast cancer-associated SNPs. The majority of these SNPs are located in noncoding regions of the genome. Yet how they contribute to breast cancer development is unknown. Recently, a groundbreaking study by the Lupien group has shown that risk-associated SNPs of breast cancer are enriched for FOXA1 binding sites, which influences the function of this transcription factor.
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spelling pubmed-37456462013-08-19 A functional link between FOXA1 and breast cancer SNPs Katika, Madhumohan R Hurtado, Antoni Breast Cancer Res Viewpoint Genome-wide association studies have revealed a multitude of breast cancer-associated SNPs. The majority of these SNPs are located in noncoding regions of the genome. Yet how they contribute to breast cancer development is unknown. Recently, a groundbreaking study by the Lupien group has shown that risk-associated SNPs of breast cancer are enriched for FOXA1 binding sites, which influences the function of this transcription factor. BioMed Central 2013 2013-02-18 /pmc/articles/PMC3745646/ /pubmed/23427833 http://dx.doi.org/10.1186/bcr3360 Text en Copyright © 2013 BioMed Central Ltd
spellingShingle Viewpoint
Katika, Madhumohan R
Hurtado, Antoni
A functional link between FOXA1 and breast cancer SNPs
title A functional link between FOXA1 and breast cancer SNPs
title_full A functional link between FOXA1 and breast cancer SNPs
title_fullStr A functional link between FOXA1 and breast cancer SNPs
title_full_unstemmed A functional link between FOXA1 and breast cancer SNPs
title_short A functional link between FOXA1 and breast cancer SNPs
title_sort functional link between foxa1 and breast cancer snps
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745646/
https://www.ncbi.nlm.nih.gov/pubmed/23427833
http://dx.doi.org/10.1186/bcr3360
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