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Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density

BACKGROUND: Bone mineral densiy (BMD) is known to be affected by serum 25-hydroxyvitamin D (25(OH) D) levels, intact parathyroid hormone (iPTH) levels. Indian data pertinent to above observation is scant. Our study aimed to investigate the relationships between serum 25-hydroxyvitamin D (25(OH) D) l...

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Autores principales: Kota, Sunil, Jammula, Sruti, Kota, Siva, Meher, Lalit, Modi, Kirtikumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745696/
https://www.ncbi.nlm.nih.gov/pubmed/23960286
http://dx.doi.org/10.4103/0019-5413.114932
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author Kota, Sunil
Jammula, Sruti
Kota, Siva
Meher, Lalit
Modi, Kirtikumar
author_facet Kota, Sunil
Jammula, Sruti
Kota, Siva
Meher, Lalit
Modi, Kirtikumar
author_sort Kota, Sunil
collection PubMed
description BACKGROUND: Bone mineral densiy (BMD) is known to be affected by serum 25-hydroxyvitamin D (25(OH) D) levels, intact parathyroid hormone (iPTH) levels. Indian data pertinent to above observation is scant. Our study aimed to investigate the relationships between serum 25-hydroxyvitamin D (25(OH) D) levels, intact parathyroid hormone (iPTH) levels and bone mineral density (BMD) in a cohort of Indian patients. MATERIALS AND METHODS: Adults with or without fragility fractures with low BMD at the hip or lumbar spine were evaluated clinically along with laboratory investigations. T-scores of the hip and spine were derived from BMD-DEXA (dual-energy X-ray absorptiometry). Multivariate regression models were used to investigate the relationships between serum 25(OH) D, iPTH and BMD. RESULTS: Total of 102 patients (male:female = 38:64) with a mean age of 62.5 ± 6.4 years were included in the study. Forty-four patients had osteopenia. Osteoporosis was present in 58 patients. The mean values for serum 25(OH) D and iPTH levels were 21.3 ± 0.5 ng/ml and 53.1 ± 22.3 pg/ml, respectively. In 84.3% of patients, serum 25(OH) D levels were below 30 ng/ml (Normal = 30-74 ng/ml), confirming vitamin D deficiency. There was no association between 25(OH) D levels and BMD at the hip or lumbar spine (P = 0.473 and 0.353, respectively). Both at the hip and lumbar spine; iPTH levels, male gender, body mass index (BMI) and age were found to be significant predictors of BMD. Patients with higher BMI had significantly lower BMD and T-score. At levels <30 ng/ml, 25(OH) D was negatively associated with iPTH (P = 0.041). CONCLUSION: Among our cohort of patients with low BMD, no direct relationship between serum 25(OH) D levels and BMD was observed. However, a negative correlation between iPTH and 25(OH) D at serum 25(OH) D concentrations <30 ng/ml. Serum iPTH levels showed a significant negative association with BMD at the hip and lumbar spine. Our findings underscore the critical role of parathyroid hormone in bone metabolism and health.
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spelling pubmed-37456962013-08-19 Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density Kota, Sunil Jammula, Sruti Kota, Siva Meher, Lalit Modi, Kirtikumar Indian J Orthop Original Article BACKGROUND: Bone mineral densiy (BMD) is known to be affected by serum 25-hydroxyvitamin D (25(OH) D) levels, intact parathyroid hormone (iPTH) levels. Indian data pertinent to above observation is scant. Our study aimed to investigate the relationships between serum 25-hydroxyvitamin D (25(OH) D) levels, intact parathyroid hormone (iPTH) levels and bone mineral density (BMD) in a cohort of Indian patients. MATERIALS AND METHODS: Adults with or without fragility fractures with low BMD at the hip or lumbar spine were evaluated clinically along with laboratory investigations. T-scores of the hip and spine were derived from BMD-DEXA (dual-energy X-ray absorptiometry). Multivariate regression models were used to investigate the relationships between serum 25(OH) D, iPTH and BMD. RESULTS: Total of 102 patients (male:female = 38:64) with a mean age of 62.5 ± 6.4 years were included in the study. Forty-four patients had osteopenia. Osteoporosis was present in 58 patients. The mean values for serum 25(OH) D and iPTH levels were 21.3 ± 0.5 ng/ml and 53.1 ± 22.3 pg/ml, respectively. In 84.3% of patients, serum 25(OH) D levels were below 30 ng/ml (Normal = 30-74 ng/ml), confirming vitamin D deficiency. There was no association between 25(OH) D levels and BMD at the hip or lumbar spine (P = 0.473 and 0.353, respectively). Both at the hip and lumbar spine; iPTH levels, male gender, body mass index (BMI) and age were found to be significant predictors of BMD. Patients with higher BMI had significantly lower BMD and T-score. At levels <30 ng/ml, 25(OH) D was negatively associated with iPTH (P = 0.041). CONCLUSION: Among our cohort of patients with low BMD, no direct relationship between serum 25(OH) D levels and BMD was observed. However, a negative correlation between iPTH and 25(OH) D at serum 25(OH) D concentrations <30 ng/ml. Serum iPTH levels showed a significant negative association with BMD at the hip and lumbar spine. Our findings underscore the critical role of parathyroid hormone in bone metabolism and health. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3745696/ /pubmed/23960286 http://dx.doi.org/10.4103/0019-5413.114932 Text en Copyright: © Indian Journal of Orthopaedics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kota, Sunil
Jammula, Sruti
Kota, Siva
Meher, Lalit
Modi, Kirtikumar
Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density
title Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density
title_full Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density
title_fullStr Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density
title_full_unstemmed Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density
title_short Correlation of vitamin D, bone mineral density and parathyroid hormone levels in adults with low bone density
title_sort correlation of vitamin d, bone mineral density and parathyroid hormone levels in adults with low bone density
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745696/
https://www.ncbi.nlm.nih.gov/pubmed/23960286
http://dx.doi.org/10.4103/0019-5413.114932
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