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Animal Models of Diabetic Neuropathy: Progress Since 1960s

Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common w...

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Autor principal: Islam, Md. Shahidul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745837/
https://www.ncbi.nlm.nih.gov/pubmed/23984428
http://dx.doi.org/10.1155/2013/149452
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author Islam, Md. Shahidul
author_facet Islam, Md. Shahidul
author_sort Islam, Md. Shahidul
collection PubMed
description Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common when rats and mice are most commonly used for many reasons. A numbers of animal models of diabetic and PDN have been developed in the last several decades such as streptozotocin-induced diabetic rat models, conventional or genetically modified or high-fat diet-fed C57BL/Ks (db/db) mice models, streptozotocin-induced C57BL6/J and ddY mice models, Chinese hamster neuropathic model, rhesus monkey PDN model, spontaneously diabetic WBN/Kob rat model, L-fucose-induced neropathic rat model, partial sciatic nerve ligated rat model, nonobese diabetic (NOD) mice model, spontaneously induced Ins2 Akita mice model, leptin-deficient (ob/ob) mice model, Otsuka Long-Evans Tokushima Fatty (OLETF) rat model, surgically-induced neuropathic model, and genetically modified Spontaneously Diabetic Torii (SDT) rat model, none of which are without limitations. An animal model of diabetic or PDN should mimic the all major pathogeneses of human diabetic neuropathy. Hence, this review comparatively evaluates the animal models of diabetic and PDN which are developed since 1960s with their advantages and disadvantages to help diabetic research groups in order to more accurately choose an appropriate model to meet their specific research objectives.
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spelling pubmed-37458372013-08-27 Animal Models of Diabetic Neuropathy: Progress Since 1960s Islam, Md. Shahidul J Diabetes Res Review Article Diabetic or peripheral diabetic neuropathy (PDN) is one of the major complications among some other diabetic complications such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. The use of animal models in the research of diabetes and diabetic complications is very common when rats and mice are most commonly used for many reasons. A numbers of animal models of diabetic and PDN have been developed in the last several decades such as streptozotocin-induced diabetic rat models, conventional or genetically modified or high-fat diet-fed C57BL/Ks (db/db) mice models, streptozotocin-induced C57BL6/J and ddY mice models, Chinese hamster neuropathic model, rhesus monkey PDN model, spontaneously diabetic WBN/Kob rat model, L-fucose-induced neropathic rat model, partial sciatic nerve ligated rat model, nonobese diabetic (NOD) mice model, spontaneously induced Ins2 Akita mice model, leptin-deficient (ob/ob) mice model, Otsuka Long-Evans Tokushima Fatty (OLETF) rat model, surgically-induced neuropathic model, and genetically modified Spontaneously Diabetic Torii (SDT) rat model, none of which are without limitations. An animal model of diabetic or PDN should mimic the all major pathogeneses of human diabetic neuropathy. Hence, this review comparatively evaluates the animal models of diabetic and PDN which are developed since 1960s with their advantages and disadvantages to help diabetic research groups in order to more accurately choose an appropriate model to meet their specific research objectives. Hindawi Publishing Corporation 2013 2013-07-29 /pmc/articles/PMC3745837/ /pubmed/23984428 http://dx.doi.org/10.1155/2013/149452 Text en Copyright © 2013 Md. Shahidul Islam. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Islam, Md. Shahidul
Animal Models of Diabetic Neuropathy: Progress Since 1960s
title Animal Models of Diabetic Neuropathy: Progress Since 1960s
title_full Animal Models of Diabetic Neuropathy: Progress Since 1960s
title_fullStr Animal Models of Diabetic Neuropathy: Progress Since 1960s
title_full_unstemmed Animal Models of Diabetic Neuropathy: Progress Since 1960s
title_short Animal Models of Diabetic Neuropathy: Progress Since 1960s
title_sort animal models of diabetic neuropathy: progress since 1960s
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745837/
https://www.ncbi.nlm.nih.gov/pubmed/23984428
http://dx.doi.org/10.1155/2013/149452
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