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Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation
Stem cells possess huge importance in developmental biology, disease modelling, cell replacement therapy, and tissue engineering in regenerative medicine because they have the remarkable potential for self-renewal and to differentiate into almost all the cell types in the human body. Elucidation of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745930/ https://www.ncbi.nlm.nih.gov/pubmed/23984388 http://dx.doi.org/10.1155/2013/623978 |
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author | Chen, Qishan Jin, Min Zhu, Jianhua Xiao, Qingzhong Zhang, Li |
author_facet | Chen, Qishan Jin, Min Zhu, Jianhua Xiao, Qingzhong Zhang, Li |
author_sort | Chen, Qishan |
collection | PubMed |
description | Stem cells possess huge importance in developmental biology, disease modelling, cell replacement therapy, and tissue engineering in regenerative medicine because they have the remarkable potential for self-renewal and to differentiate into almost all the cell types in the human body. Elucidation of molecular mechanisms regulating stem cell potency and differentiation is essential and critical for extensive application. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are modular proteins consisting of RNA-binding motifs and auxiliary domains characterized by extensive and divergent functions in nucleic acid metabolism. Multiple roles of hnRNPs in transcriptional and posttranscriptional regulation enable them to be effective gene expression regulators. More recent findings show that hnRNP proteins are crucial factors implicated in maintenance of stem cell self-renewal and pluripotency and cell differentiation. The hnRNPs interact with certain sequences in target gene promoter regions to initiate transcription. In addition, they recognize 3′UTR or 5′UTR of specific gene mRNA forming mRNP complex to regulate mRNA stability and translation. Both of these regulatory pathways lead to modulation of gene expression that is associated with stem cell proliferation, cell cycle control, pluripotency, and committed differentiation. |
format | Online Article Text |
id | pubmed-3745930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37459302013-08-27 Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation Chen, Qishan Jin, Min Zhu, Jianhua Xiao, Qingzhong Zhang, Li Biomed Res Int Review Article Stem cells possess huge importance in developmental biology, disease modelling, cell replacement therapy, and tissue engineering in regenerative medicine because they have the remarkable potential for self-renewal and to differentiate into almost all the cell types in the human body. Elucidation of molecular mechanisms regulating stem cell potency and differentiation is essential and critical for extensive application. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are modular proteins consisting of RNA-binding motifs and auxiliary domains characterized by extensive and divergent functions in nucleic acid metabolism. Multiple roles of hnRNPs in transcriptional and posttranscriptional regulation enable them to be effective gene expression regulators. More recent findings show that hnRNP proteins are crucial factors implicated in maintenance of stem cell self-renewal and pluripotency and cell differentiation. The hnRNPs interact with certain sequences in target gene promoter regions to initiate transcription. In addition, they recognize 3′UTR or 5′UTR of specific gene mRNA forming mRNP complex to regulate mRNA stability and translation. Both of these regulatory pathways lead to modulation of gene expression that is associated with stem cell proliferation, cell cycle control, pluripotency, and committed differentiation. Hindawi Publishing Corporation 2013 2013-07-29 /pmc/articles/PMC3745930/ /pubmed/23984388 http://dx.doi.org/10.1155/2013/623978 Text en Copyright © 2013 Qishan Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Qishan Jin, Min Zhu, Jianhua Xiao, Qingzhong Zhang, Li Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation |
title | Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation |
title_full | Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation |
title_fullStr | Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation |
title_full_unstemmed | Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation |
title_short | Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation |
title_sort | functions of heterogeneous nuclear ribonucleoproteins in stem cell potency and differentiation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745930/ https://www.ncbi.nlm.nih.gov/pubmed/23984388 http://dx.doi.org/10.1155/2013/623978 |
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