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Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted

BACKGROUND/AIMS: Photodynamic therapy (PDT) in unresectable cholangiocarcinoma has been associated with improved survival. We report a single tertiary care center experience over the past 6 years. METHODS: Fifty-five patients with unresectable cholangiocarcinoma received PDT between 2004 and 2010. P...

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Autores principales: Talreja, Jayant P., DeGaetani, Marisa, Ellen, Kristi, Schmitt, Timothy, Gaidhane, Monica, Kahaleh, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Gastrointestinal Endoscopy 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746145/
https://www.ncbi.nlm.nih.gov/pubmed/23964337
http://dx.doi.org/10.5946/ce.2013.46.4.390
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author Talreja, Jayant P.
DeGaetani, Marisa
Ellen, Kristi
Schmitt, Timothy
Gaidhane, Monica
Kahaleh, Michel
author_facet Talreja, Jayant P.
DeGaetani, Marisa
Ellen, Kristi
Schmitt, Timothy
Gaidhane, Monica
Kahaleh, Michel
author_sort Talreja, Jayant P.
collection PubMed
description BACKGROUND/AIMS: Photodynamic therapy (PDT) in unresectable cholangiocarcinoma has been associated with improved survival. We report a single tertiary care center experience over the past 6 years. METHODS: Fifty-five patients with unresectable cholangiocarcinoma received PDT between 2004 and 2010. Plastic stents were placed after PDT to prevent cholangitis. RESULTS: Twenty-seven patients (49%) showed Bismuth type IV, 22 (41%) showed Bismuth type III, and six (10%) showed Bismuth type I and II. Twenty patients (37%) received chemotherapy and radiation therapy, five (9%) received chemotherapy only; and one (2%) received radiation therapy only. Mean number of PDT sessions was 1.9±1.5 sessions (range, 1 to 9). Mean survival duration was 293±266 days (median, 190; range, 25 to 1,332). PDT related complications included three (5%) facial burn, three (5%) photosensitivity, and two (3%) rash. Kaplan-Meier analysis comparing the survival means of patients who received PDT and chemotherapy/radiation therapy (median survival 257 days; 95% confidence interval [CI], 166 to 528) versus who received PDT only (median survival 183 days; 95% CI, 129 to 224) showed no significant difference (log-rank p=0.20). CONCLUSIONS: PDT has a measurable impact on survival in unresectable cholangiocarcinoma but requires aggressive stenting posttherapy.
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spelling pubmed-37461452013-08-20 Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted Talreja, Jayant P. DeGaetani, Marisa Ellen, Kristi Schmitt, Timothy Gaidhane, Monica Kahaleh, Michel Clin Endosc Original Article BACKGROUND/AIMS: Photodynamic therapy (PDT) in unresectable cholangiocarcinoma has been associated with improved survival. We report a single tertiary care center experience over the past 6 years. METHODS: Fifty-five patients with unresectable cholangiocarcinoma received PDT between 2004 and 2010. Plastic stents were placed after PDT to prevent cholangitis. RESULTS: Twenty-seven patients (49%) showed Bismuth type IV, 22 (41%) showed Bismuth type III, and six (10%) showed Bismuth type I and II. Twenty patients (37%) received chemotherapy and radiation therapy, five (9%) received chemotherapy only; and one (2%) received radiation therapy only. Mean number of PDT sessions was 1.9±1.5 sessions (range, 1 to 9). Mean survival duration was 293±266 days (median, 190; range, 25 to 1,332). PDT related complications included three (5%) facial burn, three (5%) photosensitivity, and two (3%) rash. Kaplan-Meier analysis comparing the survival means of patients who received PDT and chemotherapy/radiation therapy (median survival 257 days; 95% confidence interval [CI], 166 to 528) versus who received PDT only (median survival 183 days; 95% CI, 129 to 224) showed no significant difference (log-rank p=0.20). CONCLUSIONS: PDT has a measurable impact on survival in unresectable cholangiocarcinoma but requires aggressive stenting posttherapy. The Korean Society of Gastrointestinal Endoscopy 2013-07 2013-07-31 /pmc/articles/PMC3746145/ /pubmed/23964337 http://dx.doi.org/10.5946/ce.2013.46.4.390 Text en Copyright © 2013 Korean Society of Gastrointestinal Endoscopy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Talreja, Jayant P.
DeGaetani, Marisa
Ellen, Kristi
Schmitt, Timothy
Gaidhane, Monica
Kahaleh, Michel
Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted
title Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted
title_full Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted
title_fullStr Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted
title_full_unstemmed Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted
title_short Photodynamic Therapy in Unresectable Cholangiocarcinoma: Not for the Uncommitted
title_sort photodynamic therapy in unresectable cholangiocarcinoma: not for the uncommitted
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746145/
https://www.ncbi.nlm.nih.gov/pubmed/23964337
http://dx.doi.org/10.5946/ce.2013.46.4.390
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