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Silver nanoparticles as active ingredient used for alcohol-free mouthwash
We developed an effective and non-irritant mouthwash that is alcohol-free and has a low concentration of silver nanoparticles (SNP) in order to be used for preventing oral cavity infections in immunocompromised oncologic patients. We studied antimicrobial effects of silver nanoparticles (SNP) in the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
German Medical Science GMS Publishing House
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746608/ https://www.ncbi.nlm.nih.gov/pubmed/23967391 http://dx.doi.org/10.3205/dgkh000205 |
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author | Abadi, Marzieh Fattahi Dolat Mehrabian, Sedigheh Asghari, Babak Namvar, Amirmorteza Ebrahimzadeh Ezzatifar, Fatemeh Lari, Abdolaziz Rastegar |
author_facet | Abadi, Marzieh Fattahi Dolat Mehrabian, Sedigheh Asghari, Babak Namvar, Amirmorteza Ebrahimzadeh Ezzatifar, Fatemeh Lari, Abdolaziz Rastegar |
author_sort | Abadi, Marzieh Fattahi Dolat |
collection | PubMed |
description | We developed an effective and non-irritant mouthwash that is alcohol-free and has a low concentration of silver nanoparticles (SNP) in order to be used for preventing oral cavity infections in immunocompromised oncologic patients. We studied antimicrobial effects of silver nanoparticles (SNP) in the range of (50–0.024 µg/ml) and 3% of ethanol (30,000 µg/ml) in mouthwash. Antimicrobial effects of two treatments were studied by doing challenge test on microorganisms such as Streptococcus mutans, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and measuring MIC and MBC (MFC) values of SNP toward mentioned microorganisms. These values of SNP respectively were in the range of (0.78–3.12) and (1.56–12.5 µg/ml). Results showed that SNP in the MIC and the lower concentrations killed all of the used microorganisms. No difference was observed between the antimicrobial effect of ethanol-free mouthwash containing SNP and mouthwash containing SNP and ethanol (30,000 µg/ml). SNP has high antimicrobial effects at low concentrations and it can be a good alternative for ethanol (30,000 µg/ml) because ethanol is also irritating, especially to sensitive or inflamed mucosa. |
format | Online Article Text |
id | pubmed-3746608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | German Medical Science GMS Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-37466082013-08-21 Silver nanoparticles as active ingredient used for alcohol-free mouthwash Abadi, Marzieh Fattahi Dolat Mehrabian, Sedigheh Asghari, Babak Namvar, Amirmorteza Ebrahimzadeh Ezzatifar, Fatemeh Lari, Abdolaziz Rastegar GMS Hyg Infect Control Article We developed an effective and non-irritant mouthwash that is alcohol-free and has a low concentration of silver nanoparticles (SNP) in order to be used for preventing oral cavity infections in immunocompromised oncologic patients. We studied antimicrobial effects of silver nanoparticles (SNP) in the range of (50–0.024 µg/ml) and 3% of ethanol (30,000 µg/ml) in mouthwash. Antimicrobial effects of two treatments were studied by doing challenge test on microorganisms such as Streptococcus mutans, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and measuring MIC and MBC (MFC) values of SNP toward mentioned microorganisms. These values of SNP respectively were in the range of (0.78–3.12) and (1.56–12.5 µg/ml). Results showed that SNP in the MIC and the lower concentrations killed all of the used microorganisms. No difference was observed between the antimicrobial effect of ethanol-free mouthwash containing SNP and mouthwash containing SNP and ethanol (30,000 µg/ml). SNP has high antimicrobial effects at low concentrations and it can be a good alternative for ethanol (30,000 µg/ml) because ethanol is also irritating, especially to sensitive or inflamed mucosa. German Medical Science GMS Publishing House 2013-04-29 /pmc/articles/PMC3746608/ /pubmed/23967391 http://dx.doi.org/10.3205/dgkh000205 Text en Copyright © 2013 Abadi et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/). You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Article Abadi, Marzieh Fattahi Dolat Mehrabian, Sedigheh Asghari, Babak Namvar, Amirmorteza Ebrahimzadeh Ezzatifar, Fatemeh Lari, Abdolaziz Rastegar Silver nanoparticles as active ingredient used for alcohol-free mouthwash |
title | Silver nanoparticles as active ingredient used for alcohol-free mouthwash |
title_full | Silver nanoparticles as active ingredient used for alcohol-free mouthwash |
title_fullStr | Silver nanoparticles as active ingredient used for alcohol-free mouthwash |
title_full_unstemmed | Silver nanoparticles as active ingredient used for alcohol-free mouthwash |
title_short | Silver nanoparticles as active ingredient used for alcohol-free mouthwash |
title_sort | silver nanoparticles as active ingredient used for alcohol-free mouthwash |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746608/ https://www.ncbi.nlm.nih.gov/pubmed/23967391 http://dx.doi.org/10.3205/dgkh000205 |
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