Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)

AIMS: Although the focus of therapeutic intervention has been on neurohormonal pathways thought to be harmful in heart failure (HF), such as the renin–angiotensin–aldosterone system (RAAS), potentially beneficial counter-regulatory systems are also active in HF. These promote vasodilatation and natr...

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Detalles Bibliográficos
Autores principales: McMurray, John J. V., Packer, Milton, Desai, Akshay S., Gong, Jim, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean, Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Study Design
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746839/
https://www.ncbi.nlm.nih.gov/pubmed/23563576
http://dx.doi.org/10.1093/eurjhf/hft052

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