Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor

Cancer development and chemo-resistance are often due to impaired functioning of the p53 tumor suppressor through genetic mutation or sequestration by other proteins. In glioblastoma multiforme (GBM), p53 availability is frequently reduced because it binds to the Murine Double Minute-2 (MDM2) oncopr...

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Detalles Bibliográficos
Autores principales: Costa, Barbara, Bendinelli, Sara, Gabelloni, Pamela, Da Pozzo, Eleonora, Daniele, Simona, Scatena, Fabrizio, Vanacore, Renato, Campiglia, Pietro, Bertamino, Alessia, Gomez-Monterrey, Isabel, Sorriento, Daniela, Del Giudice, Carmine, Iaccarino, Guido, Novellino, Ettore, Martini, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747081/
https://www.ncbi.nlm.nih.gov/pubmed/23977270
http://dx.doi.org/10.1371/journal.pone.0072281

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