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Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer

BACKGROUND: The incidence of the esophagogastric junction cancer is growing rapidly. The purpose of this study is to clarify the outcome of the ratio between metastatic and examined lymph nodes in esophagogastric junction cancer patients with or without 7 examined lymph nodes. METHODS: A total of 3,...

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Autores principales: Zhang, Hao, Wang, Wei, Diao, Dongmei, Cheng, Yao, Song, Yongchun, Zhu, Kun, Dang, Chengxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747090/
https://www.ncbi.nlm.nih.gov/pubmed/23977381
http://dx.doi.org/10.1371/journal.pone.0073238
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author Zhang, Hao
Wang, Wei
Diao, Dongmei
Cheng, Yao
Song, Yongchun
Zhu, Kun
Dang, Chengxue
author_facet Zhang, Hao
Wang, Wei
Diao, Dongmei
Cheng, Yao
Song, Yongchun
Zhu, Kun
Dang, Chengxue
author_sort Zhang, Hao
collection PubMed
description BACKGROUND: The incidence of the esophagogastric junction cancer is growing rapidly. The purpose of this study is to clarify the outcome of the ratio between metastatic and examined lymph nodes in esophagogastric junction cancer patients with or without 7 examined lymph nodes. METHODS: A total of 3,481 patients who underwent operation are identified from the Surveillance, Epidemiology, and End Results database. Different lymph nodes resected groups are analyzed to test the lymph nodes ratio factor. RESULTS: There are 2522 patients with 7 or more lymph nodes resected and 959 patients with less than 7 lymph nodes resected. Lymph nodes ratio and lymph node involvement are independent prognostic factors. But the lymph nodes ratio categories have a better prognostic value than the lymph node involvement categories. Compared with lymph node involvement categories, lymph nodes ratio categories represent patients with more homogeneous overall survival rate. CONCLUSIONS: This study defines that the lymph nodes ratio is an independent prognostic factor for esophagogastric junction cancer. The lymph nodes ratio can prevent stage migration and may be a helpful system to predict the prognosis of esophagogastric junction cancer patients.
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spelling pubmed-37470902013-08-23 Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer Zhang, Hao Wang, Wei Diao, Dongmei Cheng, Yao Song, Yongchun Zhu, Kun Dang, Chengxue PLoS One Research Article BACKGROUND: The incidence of the esophagogastric junction cancer is growing rapidly. The purpose of this study is to clarify the outcome of the ratio between metastatic and examined lymph nodes in esophagogastric junction cancer patients with or without 7 examined lymph nodes. METHODS: A total of 3,481 patients who underwent operation are identified from the Surveillance, Epidemiology, and End Results database. Different lymph nodes resected groups are analyzed to test the lymph nodes ratio factor. RESULTS: There are 2522 patients with 7 or more lymph nodes resected and 959 patients with less than 7 lymph nodes resected. Lymph nodes ratio and lymph node involvement are independent prognostic factors. But the lymph nodes ratio categories have a better prognostic value than the lymph node involvement categories. Compared with lymph node involvement categories, lymph nodes ratio categories represent patients with more homogeneous overall survival rate. CONCLUSIONS: This study defines that the lymph nodes ratio is an independent prognostic factor for esophagogastric junction cancer. The lymph nodes ratio can prevent stage migration and may be a helpful system to predict the prognosis of esophagogastric junction cancer patients. Public Library of Science 2013-08-19 /pmc/articles/PMC3747090/ /pubmed/23977381 http://dx.doi.org/10.1371/journal.pone.0073238 Text en © 2013 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Hao
Wang, Wei
Diao, Dongmei
Cheng, Yao
Song, Yongchun
Zhu, Kun
Dang, Chengxue
Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer
title Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer
title_full Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer
title_fullStr Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer
title_full_unstemmed Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer
title_short Ratio of Metastatic to Examined Lymph Nodes, a Helpful Staging System and Independent Prognostic Factor of Esophagogastric Junction Cancer
title_sort ratio of metastatic to examined lymph nodes, a helpful staging system and independent prognostic factor of esophagogastric junction cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747090/
https://www.ncbi.nlm.nih.gov/pubmed/23977381
http://dx.doi.org/10.1371/journal.pone.0073238
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