Akita Spontaneously Type 1 Diabetic Mice Exhibit Elevated Vascular Arginase and Impaired Vascular Endothelial and Nitrergic Function

BACKGROUND: Elevated arginase (Arg) activity is reported to be involved in diabetes-induced vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) synthase (NOS) and NO production. Akita mice, a genetic non-obese type 1 diabetes model, recapitulate human diabete...

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Detalles Bibliográficos
Autores principales: Toque, Haroldo A., Nunes, Kenia P., Yao, Lin, Xu, Zhimin, Kondrikov, Dmitry, Su, Yunchao, Webb, R. Clinton, Caldwell, Ruth B., Caldwell, R. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747112/
https://www.ncbi.nlm.nih.gov/pubmed/23977269
http://dx.doi.org/10.1371/journal.pone.0072277

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