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The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children
Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pe...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747133/ https://www.ncbi.nlm.nih.gov/pubmed/23977232 http://dx.doi.org/10.1371/journal.pone.0072141 |
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author | Ansari, Marc Uppugunduri, Chakradhara Rao S. Ferrari-Lacraz, Sylvie Bittencourt, Henrique Gumy-Pause, Fabienne Chalandon, Yves Tiercy, Jean-Marie Schechter, Tal Gassas, Adam Doyle, John D. Dupuis, Lee Duval, Michel Krajinovic, Maja Villard, Jean |
author_facet | Ansari, Marc Uppugunduri, Chakradhara Rao S. Ferrari-Lacraz, Sylvie Bittencourt, Henrique Gumy-Pause, Fabienne Chalandon, Yves Tiercy, Jean-Marie Schechter, Tal Gassas, Adam Doyle, John D. Dupuis, Lee Duval, Michel Krajinovic, Maja Villard, Jean |
author_sort | Ansari, Marc |
collection | PubMed |
description | Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1–4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I–related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti-MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes. |
format | Online Article Text |
id | pubmed-3747133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37471332013-08-23 The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children Ansari, Marc Uppugunduri, Chakradhara Rao S. Ferrari-Lacraz, Sylvie Bittencourt, Henrique Gumy-Pause, Fabienne Chalandon, Yves Tiercy, Jean-Marie Schechter, Tal Gassas, Adam Doyle, John D. Dupuis, Lee Duval, Michel Krajinovic, Maja Villard, Jean PLoS One Research Article Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1–4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I–related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti-MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes. Public Library of Science 2013-08-19 /pmc/articles/PMC3747133/ /pubmed/23977232 http://dx.doi.org/10.1371/journal.pone.0072141 Text en © 2013 Ansari et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ansari, Marc Uppugunduri, Chakradhara Rao S. Ferrari-Lacraz, Sylvie Bittencourt, Henrique Gumy-Pause, Fabienne Chalandon, Yves Tiercy, Jean-Marie Schechter, Tal Gassas, Adam Doyle, John D. Dupuis, Lee Duval, Michel Krajinovic, Maja Villard, Jean The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children |
title | The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children |
title_full | The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children |
title_fullStr | The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children |
title_full_unstemmed | The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children |
title_short | The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children |
title_sort | clinical relevance of pre-formed anti-hla and anti-mica antibodies after cord blood transplantation in children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747133/ https://www.ncbi.nlm.nih.gov/pubmed/23977232 http://dx.doi.org/10.1371/journal.pone.0072141 |
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