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The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children

Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pe...

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Autores principales: Ansari, Marc, Uppugunduri, Chakradhara Rao S., Ferrari-Lacraz, Sylvie, Bittencourt, Henrique, Gumy-Pause, Fabienne, Chalandon, Yves, Tiercy, Jean-Marie, Schechter, Tal, Gassas, Adam, Doyle, John D., Dupuis, Lee, Duval, Michel, Krajinovic, Maja, Villard, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747133/
https://www.ncbi.nlm.nih.gov/pubmed/23977232
http://dx.doi.org/10.1371/journal.pone.0072141
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author Ansari, Marc
Uppugunduri, Chakradhara Rao S.
Ferrari-Lacraz, Sylvie
Bittencourt, Henrique
Gumy-Pause, Fabienne
Chalandon, Yves
Tiercy, Jean-Marie
Schechter, Tal
Gassas, Adam
Doyle, John D.
Dupuis, Lee
Duval, Michel
Krajinovic, Maja
Villard, Jean
author_facet Ansari, Marc
Uppugunduri, Chakradhara Rao S.
Ferrari-Lacraz, Sylvie
Bittencourt, Henrique
Gumy-Pause, Fabienne
Chalandon, Yves
Tiercy, Jean-Marie
Schechter, Tal
Gassas, Adam
Doyle, John D.
Dupuis, Lee
Duval, Michel
Krajinovic, Maja
Villard, Jean
author_sort Ansari, Marc
collection PubMed
description Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1–4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I–related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti-MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes.
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spelling pubmed-37471332013-08-23 The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children Ansari, Marc Uppugunduri, Chakradhara Rao S. Ferrari-Lacraz, Sylvie Bittencourt, Henrique Gumy-Pause, Fabienne Chalandon, Yves Tiercy, Jean-Marie Schechter, Tal Gassas, Adam Doyle, John D. Dupuis, Lee Duval, Michel Krajinovic, Maja Villard, Jean PLoS One Research Article Preformed anti-HLA antibodies (AHA) are known to be associated with delayed engraftment and reduced overall survival after adult hematopoietic stem cell transplantation. However, limited data is available in pediatric patients. In this study, we explored the role of AHA on clinical outcomes in 70 pediatric patients who received a single unit of HLA mismatch cord blood for hematologic malignancies, immunodeficiencies or metabolic diseases. The presence of AHA was detected in 44% (31/70) of the patients. Preformed class I AHA was associated with an increased occurrence of grade 1–4 acute graft-versus host disease (p<0.05). The presence of anti- major-histocompatibility-complex class I–related chain A antigens (MICA) antibodies was significantly associated with a reduced platelet recovery after transplantation (p<0.05). AHA of class II with the strength of antibody titer measured as the mean fluorescence intensity above 2000 was associated with reduced event-free survival (p<0.05). A reduction of high titer of AHA and anti-MICA antibodies might have to be considered before cord blood transplantation in pediatric patients for better outcomes. Public Library of Science 2013-08-19 /pmc/articles/PMC3747133/ /pubmed/23977232 http://dx.doi.org/10.1371/journal.pone.0072141 Text en © 2013 Ansari et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ansari, Marc
Uppugunduri, Chakradhara Rao S.
Ferrari-Lacraz, Sylvie
Bittencourt, Henrique
Gumy-Pause, Fabienne
Chalandon, Yves
Tiercy, Jean-Marie
Schechter, Tal
Gassas, Adam
Doyle, John D.
Dupuis, Lee
Duval, Michel
Krajinovic, Maja
Villard, Jean
The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children
title The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children
title_full The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children
title_fullStr The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children
title_full_unstemmed The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children
title_short The Clinical Relevance of Pre-Formed Anti-HLA and Anti-MICA Antibodies after Cord Blood Transplantation in Children
title_sort clinical relevance of pre-formed anti-hla and anti-mica antibodies after cord blood transplantation in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747133/
https://www.ncbi.nlm.nih.gov/pubmed/23977232
http://dx.doi.org/10.1371/journal.pone.0072141
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