Phenyl 1,2,3-Triazole-Thymidine Ligands Stabilize G-Quadruplex DNA, Inhibit DNA Synthesis and Potentially Reduce Tumor Cell Proliferation over 3′-Azido Deoxythymidine

Triazoles are known for their non-toxicity, higher stability and therapeutic activity. Few nucleoside (L1, L2 and L3) and non-nucleoside 1,2,3-triazoles (L4–L14) were synthesised using click chemistry and they were screened for tumor cell cytotoxicity and proliferation. Among these triazole ligands...

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Detalles Bibliográficos
Autores principales: Mahesh Kumar, Jerald, Idris, Mohammed M., Srinivas, Gunda, Vinay Kumar, Pallerla, Meghah, Vuppalapaty, Kavitha, Mitta, Reddy, Chada Raji, Mainkar, Prathama S., Pal, Biswajit, Chandrasekar, Srivari, Nagesh, Narayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747139/
https://www.ncbi.nlm.nih.gov/pubmed/23976957
http://dx.doi.org/10.1371/journal.pone.0070798

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