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Changes in Effective Connectivity by Propofol Sedation
Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics obse...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747149/ https://www.ncbi.nlm.nih.gov/pubmed/23977030 http://dx.doi.org/10.1371/journal.pone.0071370 |
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author | Gómez, Francisco Phillips, Christophe Soddu, Andrea Boly, Melanie Boveroux, Pierre Vanhaudenhuyse, Audrey Bruno, Marie-Aurélie Gosseries, Olivia Bonhomme, Vincent Laureys, Steven Noirhomme, Quentin |
author_facet | Gómez, Francisco Phillips, Christophe Soddu, Andrea Boly, Melanie Boveroux, Pierre Vanhaudenhuyse, Audrey Bruno, Marie-Aurélie Gosseries, Olivia Bonhomme, Vincent Laureys, Steven Noirhomme, Quentin |
author_sort | Gómez, Francisco |
collection | PubMed |
description | Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of consciousness. We used Dynamic Causal Modeling for fMRI (fMRI-DCM) to assess how causal connectivity is influenced by the anesthetic agent in the auditory system. Our results suggest that the dynamic observed in the auditory system during unconsciousness induced by propofol, can result in a mixture of two effects: a local inhibitory connectivity increase and a decrease in the effective connectivity in sensory cortices. |
format | Online Article Text |
id | pubmed-3747149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37471492013-08-23 Changes in Effective Connectivity by Propofol Sedation Gómez, Francisco Phillips, Christophe Soddu, Andrea Boly, Melanie Boveroux, Pierre Vanhaudenhuyse, Audrey Bruno, Marie-Aurélie Gosseries, Olivia Bonhomme, Vincent Laureys, Steven Noirhomme, Quentin PLoS One Research Article Mechanisms of propofol-induced loss of consciousness remain poorly understood. Recent fMRI studies have shown decreases in functional connectivity during unconsciousness induced by this anesthetic agent. Functional connectivity does not provide information of directional changes in the dynamics observed during unconsciousness. The aim of the present study was to investigate, in healthy humans during an auditory task, the changes in effective connectivity resulting from propofol induced loss of consciousness. We used Dynamic Causal Modeling for fMRI (fMRI-DCM) to assess how causal connectivity is influenced by the anesthetic agent in the auditory system. Our results suggest that the dynamic observed in the auditory system during unconsciousness induced by propofol, can result in a mixture of two effects: a local inhibitory connectivity increase and a decrease in the effective connectivity in sensory cortices. Public Library of Science 2013-08-19 /pmc/articles/PMC3747149/ /pubmed/23977030 http://dx.doi.org/10.1371/journal.pone.0071370 Text en © 2013 Gómez et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Gómez, Francisco Phillips, Christophe Soddu, Andrea Boly, Melanie Boveroux, Pierre Vanhaudenhuyse, Audrey Bruno, Marie-Aurélie Gosseries, Olivia Bonhomme, Vincent Laureys, Steven Noirhomme, Quentin Changes in Effective Connectivity by Propofol Sedation |
title | Changes in Effective Connectivity by Propofol Sedation |
title_full | Changes in Effective Connectivity by Propofol Sedation |
title_fullStr | Changes in Effective Connectivity by Propofol Sedation |
title_full_unstemmed | Changes in Effective Connectivity by Propofol Sedation |
title_short | Changes in Effective Connectivity by Propofol Sedation |
title_sort | changes in effective connectivity by propofol sedation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747149/ https://www.ncbi.nlm.nih.gov/pubmed/23977030 http://dx.doi.org/10.1371/journal.pone.0071370 |
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