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Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates

BACKGROUND: In chronic PTSD, a preattentive neural alarm system responds rapidly to emotional information, leading to increased prefrontal cortex (PFC) activation at early processing stages (<100 ms). Enhanced PFC responses are followed by a reduction in occipito-temporal activity during later pr...

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Autores principales: Burgmer, Markus, Rehbein, Maimu Alissa, Wrenger, Marco, Kandil, Judith, Heuft, Gereon, Steinberg, Christian, Pfleiderer, Bettina, Junghöfer, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747150/
https://www.ncbi.nlm.nih.gov/pubmed/23977010
http://dx.doi.org/10.1371/journal.pone.0071289
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author Burgmer, Markus
Rehbein, Maimu Alissa
Wrenger, Marco
Kandil, Judith
Heuft, Gereon
Steinberg, Christian
Pfleiderer, Bettina
Junghöfer, Markus
author_facet Burgmer, Markus
Rehbein, Maimu Alissa
Wrenger, Marco
Kandil, Judith
Heuft, Gereon
Steinberg, Christian
Pfleiderer, Bettina
Junghöfer, Markus
author_sort Burgmer, Markus
collection PubMed
description BACKGROUND: In chronic PTSD, a preattentive neural alarm system responds rapidly to emotional information, leading to increased prefrontal cortex (PFC) activation at early processing stages (<100 ms). Enhanced PFC responses are followed by a reduction in occipito-temporal activity during later processing stages. However, it remains unknown if this neuronal pattern is a result of a long lasting mental disorder or if it represents changes in brain function as direct consequences of severe trauma. METHODOLOGY: The present study investigates early fear network activity in acutely traumatized patients with PTSD. It focuses on the question whether dysfunctions previously observed in chronic PTSD patients are already present shortly after trauma exposure. We recorded neuromagnetic activity towards emotional pictures in seven acutely traumatized PTSD patients between one and seven weeks after trauma exposure and compared brain responses to a balanced healthy control sample. Inverse modelling served for mapping sources of differential activation in the brain. PRINCIPAL FINDINGS: Compared to the control group, acutely traumatized PTSD patients showed an enhanced PFC response to high-arousing pictures between 60 to 80 ms. This rapid prefrontal hypervigilance towards arousing pictorial stimuli was sustained during 120–300 ms, where it was accompanied by a reduced affective modulation of occipito-temporal neural processing. CONCLUSIONS: Our findings indicate that the hypervigilance-avoidance pattern seen in chronic PTSD is not necessarily a product of an endured mental disorder, but arises as an almost immediate result of severe traumatisation. Thus, traumatic experiences can influence emotion processing strongly, leading to long-lasting changes in trauma network activation and expediting a chronic manifestation of maladaptive cognitive and behavioral symptoms.
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spelling pubmed-37471502013-08-23 Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates Burgmer, Markus Rehbein, Maimu Alissa Wrenger, Marco Kandil, Judith Heuft, Gereon Steinberg, Christian Pfleiderer, Bettina Junghöfer, Markus PLoS One Research Article BACKGROUND: In chronic PTSD, a preattentive neural alarm system responds rapidly to emotional information, leading to increased prefrontal cortex (PFC) activation at early processing stages (<100 ms). Enhanced PFC responses are followed by a reduction in occipito-temporal activity during later processing stages. However, it remains unknown if this neuronal pattern is a result of a long lasting mental disorder or if it represents changes in brain function as direct consequences of severe trauma. METHODOLOGY: The present study investigates early fear network activity in acutely traumatized patients with PTSD. It focuses on the question whether dysfunctions previously observed in chronic PTSD patients are already present shortly after trauma exposure. We recorded neuromagnetic activity towards emotional pictures in seven acutely traumatized PTSD patients between one and seven weeks after trauma exposure and compared brain responses to a balanced healthy control sample. Inverse modelling served for mapping sources of differential activation in the brain. PRINCIPAL FINDINGS: Compared to the control group, acutely traumatized PTSD patients showed an enhanced PFC response to high-arousing pictures between 60 to 80 ms. This rapid prefrontal hypervigilance towards arousing pictorial stimuli was sustained during 120–300 ms, where it was accompanied by a reduced affective modulation of occipito-temporal neural processing. CONCLUSIONS: Our findings indicate that the hypervigilance-avoidance pattern seen in chronic PTSD is not necessarily a product of an endured mental disorder, but arises as an almost immediate result of severe traumatisation. Thus, traumatic experiences can influence emotion processing strongly, leading to long-lasting changes in trauma network activation and expediting a chronic manifestation of maladaptive cognitive and behavioral symptoms. Public Library of Science 2013-08-19 /pmc/articles/PMC3747150/ /pubmed/23977010 http://dx.doi.org/10.1371/journal.pone.0071289 Text en © 2013 Burgmer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Burgmer, Markus
Rehbein, Maimu Alissa
Wrenger, Marco
Kandil, Judith
Heuft, Gereon
Steinberg, Christian
Pfleiderer, Bettina
Junghöfer, Markus
Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates
title Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates
title_full Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates
title_fullStr Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates
title_full_unstemmed Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates
title_short Early Affective Processing in Patients with Acute Posttraumatic Stress Disorder: Magnetoencephalographic Correlates
title_sort early affective processing in patients with acute posttraumatic stress disorder: magnetoencephalographic correlates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747150/
https://www.ncbi.nlm.nih.gov/pubmed/23977010
http://dx.doi.org/10.1371/journal.pone.0071289
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