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Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers
BACKGROUND: Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx. This study aimed to determine whether disruption of galectin-3 multimerization and insertion of synthetic...
Autores principales: | Mauris, Jerome, Mantelli, Flavio, Woodward, Ashley M., Cao, Ziyhi, Bertozzi, Carolyn R., Panjwani, Noorjahan, Godula, Kamil, Argüeso, Pablo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747151/ https://www.ncbi.nlm.nih.gov/pubmed/23977277 http://dx.doi.org/10.1371/journal.pone.0072304 |
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