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Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis

BACKGROUND: Studies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue. METHODS: A literature search of electronic databases was performed for articles published t...

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Autores principales: Sgolastra, Fabrizio, Petrucci, Ambra, Severino, Marco, Gatto, Roberto, Monaco, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747173/
https://www.ncbi.nlm.nih.gov/pubmed/23990948
http://dx.doi.org/10.1371/journal.pone.0071387
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author Sgolastra, Fabrizio
Petrucci, Ambra
Severino, Marco
Gatto, Roberto
Monaco, Annalisa
author_facet Sgolastra, Fabrizio
Petrucci, Ambra
Severino, Marco
Gatto, Roberto
Monaco, Annalisa
author_sort Sgolastra, Fabrizio
collection PubMed
description BACKGROUND: Studies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue. METHODS: A literature search of electronic databases was performed for articles published through March 24, 2013, followed by a manual search of several dental and medical journals. The meta-analysis was conducted according to the recommendations of the Cochrane Collaboration and PRISMA. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the χ(2)-based Cochran Q test and I(2) statistic. The level of significance was set at P <0.05. RESULTS: Fifteen studies were included, including three cohort and 12 case-control studies. A positive association was found between PE and PD (OR 2.17, 95% CI 1.38–3.41, P = 0.0008). However, a high and significant heterogeneity was found (χ(2) = 62.42, P<0.00001, I(2) = 75%). In most cases, subgroup analysis had low power to detect significant differences between PE and non-PE groups. CONCLUSION: Based on the findings of the meta-analysis, PD appears to be a possible risk factor for PE. However, given the important differences in the definitions and diagnoses of PD and PE among the studies, as well as their lack of good methodological quality, future trials are needed to confirm the results of the present meta-analysis.
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spelling pubmed-37471732013-08-29 Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis Sgolastra, Fabrizio Petrucci, Ambra Severino, Marco Gatto, Roberto Monaco, Annalisa PLoS One Research Article BACKGROUND: Studies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue. METHODS: A literature search of electronic databases was performed for articles published through March 24, 2013, followed by a manual search of several dental and medical journals. The meta-analysis was conducted according to the recommendations of the Cochrane Collaboration and PRISMA. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the χ(2)-based Cochran Q test and I(2) statistic. The level of significance was set at P <0.05. RESULTS: Fifteen studies were included, including three cohort and 12 case-control studies. A positive association was found between PE and PD (OR 2.17, 95% CI 1.38–3.41, P = 0.0008). However, a high and significant heterogeneity was found (χ(2) = 62.42, P<0.00001, I(2) = 75%). In most cases, subgroup analysis had low power to detect significant differences between PE and non-PE groups. CONCLUSION: Based on the findings of the meta-analysis, PD appears to be a possible risk factor for PE. However, given the important differences in the definitions and diagnoses of PD and PE among the studies, as well as their lack of good methodological quality, future trials are needed to confirm the results of the present meta-analysis. Public Library of Science 2013-08-19 /pmc/articles/PMC3747173/ /pubmed/23990948 http://dx.doi.org/10.1371/journal.pone.0071387 Text en © 2013 Sgolastra et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sgolastra, Fabrizio
Petrucci, Ambra
Severino, Marco
Gatto, Roberto
Monaco, Annalisa
Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis
title Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis
title_full Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis
title_fullStr Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis
title_full_unstemmed Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis
title_short Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis
title_sort relationship between periodontitis and pre-eclampsia: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747173/
https://www.ncbi.nlm.nih.gov/pubmed/23990948
http://dx.doi.org/10.1371/journal.pone.0071387
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