Cargando…
Alternative Splicing Programs in Prostate Cancer
Prostate cancer (PCa) remains one of the most frequent causes of death for cancer in the male population. Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer rend...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747374/ https://www.ncbi.nlm.nih.gov/pubmed/23983695 http://dx.doi.org/10.1155/2013/458727 |
_version_ | 1782280920531730432 |
---|---|
author | Sette, Claudio |
author_facet | Sette, Claudio |
author_sort | Sette, Claudio |
collection | PubMed |
description | Prostate cancer (PCa) remains one of the most frequent causes of death for cancer in the male population. Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer renders its diagnosis and cure particularly challenging. Mounting evidence indicates that alternative splicing, the process that allows production of multiple mRNA variants from each gene, contributes to the heterogeneity of the disease. Key genes for the biology of normal and neoplastic prostate cells, such as those encoding for the androgen receptor and cyclin D1, are alternatively spliced to yield protein isoforms with different or even opposing functions. This review illustrates some examples of genes whose alternative splicing regulation is relevant to PCa biology and discusses the possibility to exploit alternative splicing regulation as a novel tool for prognosis, diagnosis, and therapeutic approaches to PCa. |
format | Online Article Text |
id | pubmed-3747374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37473742013-08-27 Alternative Splicing Programs in Prostate Cancer Sette, Claudio Int J Cell Biol Review Article Prostate cancer (PCa) remains one of the most frequent causes of death for cancer in the male population. Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. The genetic and phenotypic heterogeneity of this type of cancer renders its diagnosis and cure particularly challenging. Mounting evidence indicates that alternative splicing, the process that allows production of multiple mRNA variants from each gene, contributes to the heterogeneity of the disease. Key genes for the biology of normal and neoplastic prostate cells, such as those encoding for the androgen receptor and cyclin D1, are alternatively spliced to yield protein isoforms with different or even opposing functions. This review illustrates some examples of genes whose alternative splicing regulation is relevant to PCa biology and discusses the possibility to exploit alternative splicing regulation as a novel tool for prognosis, diagnosis, and therapeutic approaches to PCa. Hindawi Publishing Corporation 2013 2013-08-01 /pmc/articles/PMC3747374/ /pubmed/23983695 http://dx.doi.org/10.1155/2013/458727 Text en Copyright © 2013 Claudio Sette. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sette, Claudio Alternative Splicing Programs in Prostate Cancer |
title | Alternative Splicing Programs in Prostate Cancer |
title_full | Alternative Splicing Programs in Prostate Cancer |
title_fullStr | Alternative Splicing Programs in Prostate Cancer |
title_full_unstemmed | Alternative Splicing Programs in Prostate Cancer |
title_short | Alternative Splicing Programs in Prostate Cancer |
title_sort | alternative splicing programs in prostate cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747374/ https://www.ncbi.nlm.nih.gov/pubmed/23983695 http://dx.doi.org/10.1155/2013/458727 |
work_keys_str_mv | AT setteclaudio alternativesplicingprogramsinprostatecancer |