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Exercise and the Aging Endothelium

The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis. Indeed, age is an independent risk...

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Detalles Bibliográficos
Autores principales: Golbidi, Saeid, Laher, Ismail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747387/
https://www.ncbi.nlm.nih.gov/pubmed/23984434
http://dx.doi.org/10.1155/2013/789607
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author Golbidi, Saeid
Laher, Ismail
author_facet Golbidi, Saeid
Laher, Ismail
author_sort Golbidi, Saeid
collection PubMed
description The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis. Indeed, age is an independent risk factor for cardiovascular diseases and is in part an important factor in the increased exponential mortality rates from vascular disease such as myocardial infarction and stroke that occurs in the ageing population. There are a number of mechanisms suggested to explain age-related endothelial dysfunction. However, recent scientific studies have advanced the notion of oxidative stress and inflammation as the two major risk factors underlying aging and age-related diseases. Regular physical activity, known to have a favorable effect on cardiovascular health, can also improve the function of the ageing endothelium by modulating oxidative stress and inflammatory processes, as we discuss in this paper.
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spelling pubmed-37473872013-08-27 Exercise and the Aging Endothelium Golbidi, Saeid Laher, Ismail J Diabetes Res Review Article The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis. Indeed, age is an independent risk factor for cardiovascular diseases and is in part an important factor in the increased exponential mortality rates from vascular disease such as myocardial infarction and stroke that occurs in the ageing population. There are a number of mechanisms suggested to explain age-related endothelial dysfunction. However, recent scientific studies have advanced the notion of oxidative stress and inflammation as the two major risk factors underlying aging and age-related diseases. Regular physical activity, known to have a favorable effect on cardiovascular health, can also improve the function of the ageing endothelium by modulating oxidative stress and inflammatory processes, as we discuss in this paper. Hindawi Publishing Corporation 2013 2013-08-01 /pmc/articles/PMC3747387/ /pubmed/23984434 http://dx.doi.org/10.1155/2013/789607 Text en Copyright © 2013 S. Golbidi and I. Laher. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Golbidi, Saeid
Laher, Ismail
Exercise and the Aging Endothelium
title Exercise and the Aging Endothelium
title_full Exercise and the Aging Endothelium
title_fullStr Exercise and the Aging Endothelium
title_full_unstemmed Exercise and the Aging Endothelium
title_short Exercise and the Aging Endothelium
title_sort exercise and the aging endothelium
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747387/
https://www.ncbi.nlm.nih.gov/pubmed/23984434
http://dx.doi.org/10.1155/2013/789607
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