Cargando…

Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root

Root aqueous extract of Lecaniodiscus cupanioides was evaluated for antimalarial activity and analyzed for its phytochemical constituents. Twenty-four (24) albino mice were infected by intraperitoneal injection of standard inoculum of chloroquine sensitive Plasmodium berghei (NK 65). The animals wer...

Descripción completa

Detalles Bibliográficos
Autores principales: Nafiu, Mikhail Olugbemiro, Abdulsalam, Taoheed Adedeji, Akanji, Musbau Adewumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747395/
https://www.ncbi.nlm.nih.gov/pubmed/23983718
http://dx.doi.org/10.1155/2013/605393
_version_ 1782280925529243648
author Nafiu, Mikhail Olugbemiro
Abdulsalam, Taoheed Adedeji
Akanji, Musbau Adewumi
author_facet Nafiu, Mikhail Olugbemiro
Abdulsalam, Taoheed Adedeji
Akanji, Musbau Adewumi
author_sort Nafiu, Mikhail Olugbemiro
collection PubMed
description Root aqueous extract of Lecaniodiscus cupanioides was evaluated for antimalarial activity and analyzed for its phytochemical constituents. Twenty-four (24) albino mice were infected by intraperitoneal injection of standard inoculum of chloroquine sensitive Plasmodium berghei (NK 65). The animals were randomly divided into 6 groups of 3 mice each. Group 1 served as the control while groups II–IV were orally administered 50, 150, and 250 mg/kg body weights of extract. Groups 5 and 6 received 1.75 and 5 mg/kg of artesunate and chloroquine, respectively. The results of the phytochemical analysis showed the presence of alkaloids (2.37%), saponin (0.336), tannin (0.012 per cent), phenol (0.008 per cent), and anthraquinone (0.002 per cent). There was 100 per cent parasite inhibition in the chloroquine group and 70 per cent in the 50 mg/kg body weight on day 12, respectively. The mean survival time (MST), for the control group was 14 days, artesunate 16 days, and chloroquine 30 days, while the groups that received 50 and 250 mg/kg body weight recorded similar MST of 17 days and the 150 mg/kg body weight group recorded 19 days. The results obtained indicated that the aqueous extract of Lecaniodiscus cupanioides may provide an alternative antimalarial.
format Online
Article
Text
id pubmed-3747395
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37473952013-08-27 Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root Nafiu, Mikhail Olugbemiro Abdulsalam, Taoheed Adedeji Akanji, Musbau Adewumi J Trop Med Research Article Root aqueous extract of Lecaniodiscus cupanioides was evaluated for antimalarial activity and analyzed for its phytochemical constituents. Twenty-four (24) albino mice were infected by intraperitoneal injection of standard inoculum of chloroquine sensitive Plasmodium berghei (NK 65). The animals were randomly divided into 6 groups of 3 mice each. Group 1 served as the control while groups II–IV were orally administered 50, 150, and 250 mg/kg body weights of extract. Groups 5 and 6 received 1.75 and 5 mg/kg of artesunate and chloroquine, respectively. The results of the phytochemical analysis showed the presence of alkaloids (2.37%), saponin (0.336), tannin (0.012 per cent), phenol (0.008 per cent), and anthraquinone (0.002 per cent). There was 100 per cent parasite inhibition in the chloroquine group and 70 per cent in the 50 mg/kg body weight on day 12, respectively. The mean survival time (MST), for the control group was 14 days, artesunate 16 days, and chloroquine 30 days, while the groups that received 50 and 250 mg/kg body weight recorded similar MST of 17 days and the 150 mg/kg body weight group recorded 19 days. The results obtained indicated that the aqueous extract of Lecaniodiscus cupanioides may provide an alternative antimalarial. Hindawi Publishing Corporation 2013 2013-08-01 /pmc/articles/PMC3747395/ /pubmed/23983718 http://dx.doi.org/10.1155/2013/605393 Text en Copyright © 2013 Mikhail Olugbemiro Nafiu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nafiu, Mikhail Olugbemiro
Abdulsalam, Taoheed Adedeji
Akanji, Musbau Adewumi
Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root
title Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root
title_full Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root
title_fullStr Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root
title_full_unstemmed Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root
title_short Phytochemical Analysis and Antimalarial Activity Aqueous Extract of Lecaniodiscus cupanioides Root
title_sort phytochemical analysis and antimalarial activity aqueous extract of lecaniodiscus cupanioides root
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747395/
https://www.ncbi.nlm.nih.gov/pubmed/23983718
http://dx.doi.org/10.1155/2013/605393
work_keys_str_mv AT nafiumikhailolugbemiro phytochemicalanalysisandantimalarialactivityaqueousextractoflecaniodiscuscupanioidesroot
AT abdulsalamtaoheedadedeji phytochemicalanalysisandantimalarialactivityaqueousextractoflecaniodiscuscupanioidesroot
AT akanjimusbauadewumi phytochemicalanalysisandantimalarialactivityaqueousextractoflecaniodiscuscupanioidesroot