Cargando…

Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools

The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integrat...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Ming, Chen, Jia-Lei, Xu, Li-Wen, Ji, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747450/
https://www.ncbi.nlm.nih.gov/pubmed/23983798
http://dx.doi.org/10.1155/2013/731969
_version_ 1782280938245324800
author Yang, Ming
Chen, Jia-Lei
Xu, Li-Wen
Ji, Guang
author_facet Yang, Ming
Chen, Jia-Lei
Xu, Li-Wen
Ji, Guang
author_sort Yang, Ming
collection PubMed
description The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integration data analysis strategy and interpretable visualization provides deeper insights into the underlying mechanisms of TCM theories, including the principles of herb combination, biological foundations of herb or herbal formulae action, and molecular basis of TCM syndromes. In this study, we review several recent developments in TCM network pharmacology research and discuss their potential for bridging the gap between traditional and modern medicine. We briefly summarize the two main functional applications of TCM network models: understanding/uncovering and predicting/discovering. In particular, we focus on how TCM network pharmacology research is conducted and highlight different computational tools, such as network-based and machine learning algorithms, and sources that have been proposed and applied to the different steps involved in the research process. To make network pharmacology research commonplace, some basic network definitions and analysis methods are presented.
format Online
Article
Text
id pubmed-3747450
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37474502013-08-27 Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools Yang, Ming Chen, Jia-Lei Xu, Li-Wen Ji, Guang Evid Based Complement Alternat Med Review Article The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integration data analysis strategy and interpretable visualization provides deeper insights into the underlying mechanisms of TCM theories, including the principles of herb combination, biological foundations of herb or herbal formulae action, and molecular basis of TCM syndromes. In this study, we review several recent developments in TCM network pharmacology research and discuss their potential for bridging the gap between traditional and modern medicine. We briefly summarize the two main functional applications of TCM network models: understanding/uncovering and predicting/discovering. In particular, we focus on how TCM network pharmacology research is conducted and highlight different computational tools, such as network-based and machine learning algorithms, and sources that have been proposed and applied to the different steps involved in the research process. To make network pharmacology research commonplace, some basic network definitions and analysis methods are presented. Hindawi Publishing Corporation 2013 2013-07-31 /pmc/articles/PMC3747450/ /pubmed/23983798 http://dx.doi.org/10.1155/2013/731969 Text en Copyright © 2013 Ming Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Ming
Chen, Jia-Lei
Xu, Li-Wen
Ji, Guang
Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools
title Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools
title_full Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools
title_fullStr Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools
title_full_unstemmed Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools
title_short Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools
title_sort navigating traditional chinese medicine network pharmacology and computational tools
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747450/
https://www.ncbi.nlm.nih.gov/pubmed/23983798
http://dx.doi.org/10.1155/2013/731969
work_keys_str_mv AT yangming navigatingtraditionalchinesemedicinenetworkpharmacologyandcomputationaltools
AT chenjialei navigatingtraditionalchinesemedicinenetworkpharmacologyandcomputationaltools
AT xuliwen navigatingtraditionalchinesemedicinenetworkpharmacologyandcomputationaltools
AT jiguang navigatingtraditionalchinesemedicinenetworkpharmacologyandcomputationaltools