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Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools
The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integrat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747450/ https://www.ncbi.nlm.nih.gov/pubmed/23983798 http://dx.doi.org/10.1155/2013/731969 |
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author | Yang, Ming Chen, Jia-Lei Xu, Li-Wen Ji, Guang |
author_facet | Yang, Ming Chen, Jia-Lei Xu, Li-Wen Ji, Guang |
author_sort | Yang, Ming |
collection | PubMed |
description | The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integration data analysis strategy and interpretable visualization provides deeper insights into the underlying mechanisms of TCM theories, including the principles of herb combination, biological foundations of herb or herbal formulae action, and molecular basis of TCM syndromes. In this study, we review several recent developments in TCM network pharmacology research and discuss their potential for bridging the gap between traditional and modern medicine. We briefly summarize the two main functional applications of TCM network models: understanding/uncovering and predicting/discovering. In particular, we focus on how TCM network pharmacology research is conducted and highlight different computational tools, such as network-based and machine learning algorithms, and sources that have been proposed and applied to the different steps involved in the research process. To make network pharmacology research commonplace, some basic network definitions and analysis methods are presented. |
format | Online Article Text |
id | pubmed-3747450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37474502013-08-27 Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools Yang, Ming Chen, Jia-Lei Xu, Li-Wen Ji, Guang Evid Based Complement Alternat Med Review Article The concept of “network target” has ushered in a new era in the field of traditional Chinese medicine (TCM). As a new research approach, network pharmacology is based on the analysis of network models and systems biology. Taking advantage of advancements in systems biology, a high degree of integration data analysis strategy and interpretable visualization provides deeper insights into the underlying mechanisms of TCM theories, including the principles of herb combination, biological foundations of herb or herbal formulae action, and molecular basis of TCM syndromes. In this study, we review several recent developments in TCM network pharmacology research and discuss their potential for bridging the gap between traditional and modern medicine. We briefly summarize the two main functional applications of TCM network models: understanding/uncovering and predicting/discovering. In particular, we focus on how TCM network pharmacology research is conducted and highlight different computational tools, such as network-based and machine learning algorithms, and sources that have been proposed and applied to the different steps involved in the research process. To make network pharmacology research commonplace, some basic network definitions and analysis methods are presented. Hindawi Publishing Corporation 2013 2013-07-31 /pmc/articles/PMC3747450/ /pubmed/23983798 http://dx.doi.org/10.1155/2013/731969 Text en Copyright © 2013 Ming Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yang, Ming Chen, Jia-Lei Xu, Li-Wen Ji, Guang Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools |
title | Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools |
title_full | Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools |
title_fullStr | Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools |
title_full_unstemmed | Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools |
title_short | Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools |
title_sort | navigating traditional chinese medicine network pharmacology and computational tools |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747450/ https://www.ncbi.nlm.nih.gov/pubmed/23983798 http://dx.doi.org/10.1155/2013/731969 |
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