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Heparin and Related Drugs: Beyond Anticoagulant Activity

Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of...

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Autor principal: Page, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747464/
https://www.ncbi.nlm.nih.gov/pubmed/23984092
http://dx.doi.org/10.1155/2013/910743
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author Page, Clive
author_facet Page, Clive
author_sort Page, Clive
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description Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that retain the anti-inflammatory activity. Heparin exhibits anti-inflammatory activities via a variety of mechanisms including neutralization of cationic mediators, inhibition of adhesion molecules, and the inhibition of heparanase, all involved in leukocyte recruitment into tissues. It is anticipated that furthering our understanding of the anti-inflammatory actions of heparin will lead to the development of novel anti-inflammatory drugs for a variety of clinical indications.
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spelling pubmed-37474642013-08-27 Heparin and Related Drugs: Beyond Anticoagulant Activity Page, Clive ISRN Pharmacol Review Article Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that retain the anti-inflammatory activity. Heparin exhibits anti-inflammatory activities via a variety of mechanisms including neutralization of cationic mediators, inhibition of adhesion molecules, and the inhibition of heparanase, all involved in leukocyte recruitment into tissues. It is anticipated that furthering our understanding of the anti-inflammatory actions of heparin will lead to the development of novel anti-inflammatory drugs for a variety of clinical indications. Hindawi Publishing Corporation 2013-07-30 /pmc/articles/PMC3747464/ /pubmed/23984092 http://dx.doi.org/10.1155/2013/910743 Text en Copyright © 2013 Clive Page. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Page, Clive
Heparin and Related Drugs: Beyond Anticoagulant Activity
title Heparin and Related Drugs: Beyond Anticoagulant Activity
title_full Heparin and Related Drugs: Beyond Anticoagulant Activity
title_fullStr Heparin and Related Drugs: Beyond Anticoagulant Activity
title_full_unstemmed Heparin and Related Drugs: Beyond Anticoagulant Activity
title_short Heparin and Related Drugs: Beyond Anticoagulant Activity
title_sort heparin and related drugs: beyond anticoagulant activity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747464/
https://www.ncbi.nlm.nih.gov/pubmed/23984092
http://dx.doi.org/10.1155/2013/910743
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