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Heparin and Related Drugs: Beyond Anticoagulant Activity
Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747464/ https://www.ncbi.nlm.nih.gov/pubmed/23984092 http://dx.doi.org/10.1155/2013/910743 |
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author | Page, Clive |
author_facet | Page, Clive |
author_sort | Page, Clive |
collection | PubMed |
description | Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that retain the anti-inflammatory activity. Heparin exhibits anti-inflammatory activities via a variety of mechanisms including neutralization of cationic mediators, inhibition of adhesion molecules, and the inhibition of heparanase, all involved in leukocyte recruitment into tissues. It is anticipated that furthering our understanding of the anti-inflammatory actions of heparin will lead to the development of novel anti-inflammatory drugs for a variety of clinical indications. |
format | Online Article Text |
id | pubmed-3747464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37474642013-08-27 Heparin and Related Drugs: Beyond Anticoagulant Activity Page, Clive ISRN Pharmacol Review Article Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that retain the anti-inflammatory activity. Heparin exhibits anti-inflammatory activities via a variety of mechanisms including neutralization of cationic mediators, inhibition of adhesion molecules, and the inhibition of heparanase, all involved in leukocyte recruitment into tissues. It is anticipated that furthering our understanding of the anti-inflammatory actions of heparin will lead to the development of novel anti-inflammatory drugs for a variety of clinical indications. Hindawi Publishing Corporation 2013-07-30 /pmc/articles/PMC3747464/ /pubmed/23984092 http://dx.doi.org/10.1155/2013/910743 Text en Copyright © 2013 Clive Page. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Page, Clive Heparin and Related Drugs: Beyond Anticoagulant Activity |
title | Heparin and Related Drugs: Beyond Anticoagulant Activity |
title_full | Heparin and Related Drugs: Beyond Anticoagulant Activity |
title_fullStr | Heparin and Related Drugs: Beyond Anticoagulant Activity |
title_full_unstemmed | Heparin and Related Drugs: Beyond Anticoagulant Activity |
title_short | Heparin and Related Drugs: Beyond Anticoagulant Activity |
title_sort | heparin and related drugs: beyond anticoagulant activity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747464/ https://www.ncbi.nlm.nih.gov/pubmed/23984092 http://dx.doi.org/10.1155/2013/910743 |
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