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Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression

Breast cancer is defined as a cancer originating in tissues of the breast, frequently in ducts and lobules. During the last 30 years, studies to understand the biology and to treat breast tumor improved patients' survival rates. These studies have focused on genetic components involved in tumor...

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Detalles Bibliográficos
Autores principales: Gomes, Angélica M., Stelling, Mariana P., Pavão, Mauro S. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747466/
https://www.ncbi.nlm.nih.gov/pubmed/23984412
http://dx.doi.org/10.1155/2013/852093
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author Gomes, Angélica M.
Stelling, Mariana P.
Pavão, Mauro S. G.
author_facet Gomes, Angélica M.
Stelling, Mariana P.
Pavão, Mauro S. G.
author_sort Gomes, Angélica M.
collection PubMed
description Breast cancer is defined as a cancer originating in tissues of the breast, frequently in ducts and lobules. During the last 30 years, studies to understand the biology and to treat breast tumor improved patients' survival rates. These studies have focused on genetic components involved in tumor progression and on tumor microenvironment. Heparan sulfate proteoglycans (HSPGs) are involved in cell signaling, adhesion, extracellular matrix assembly, and growth factors storage. As a central molecule, HSPG regulates cell behavior and tumor progression. HS accompanied by its glycosaminoglycan counterparts regulates tissue homeostasis and cancer development. These molecules present opposite effects according to tumor type or cancer model. Studies in this area may contribute to unveil glycosaminoglycan activities on cell dynamics during breast cancer exploring these polysaccharides as antitumor agents. Heparanase is a potent tumor modulator due to its protumorigenic, proangiogenic, and prometastatic activities. Several lines of evidence indicate that heparanase is upregulated in all human sarcomas and carcinomas. Heparanase seems to be related to several aspects regulating the potential of breast cancer metastasis. Due to its multiple roles, heparanase is seen as a target in cancer treatment. We will describe recent findings on the function of HSPGs and heparanase in breast cancer behavior and progression.
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spelling pubmed-37474662013-08-27 Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression Gomes, Angélica M. Stelling, Mariana P. Pavão, Mauro S. G. Biomed Res Int Review Article Breast cancer is defined as a cancer originating in tissues of the breast, frequently in ducts and lobules. During the last 30 years, studies to understand the biology and to treat breast tumor improved patients' survival rates. These studies have focused on genetic components involved in tumor progression and on tumor microenvironment. Heparan sulfate proteoglycans (HSPGs) are involved in cell signaling, adhesion, extracellular matrix assembly, and growth factors storage. As a central molecule, HSPG regulates cell behavior and tumor progression. HS accompanied by its glycosaminoglycan counterparts regulates tissue homeostasis and cancer development. These molecules present opposite effects according to tumor type or cancer model. Studies in this area may contribute to unveil glycosaminoglycan activities on cell dynamics during breast cancer exploring these polysaccharides as antitumor agents. Heparanase is a potent tumor modulator due to its protumorigenic, proangiogenic, and prometastatic activities. Several lines of evidence indicate that heparanase is upregulated in all human sarcomas and carcinomas. Heparanase seems to be related to several aspects regulating the potential of breast cancer metastasis. Due to its multiple roles, heparanase is seen as a target in cancer treatment. We will describe recent findings on the function of HSPGs and heparanase in breast cancer behavior and progression. Hindawi Publishing Corporation 2013 2013-07-31 /pmc/articles/PMC3747466/ /pubmed/23984412 http://dx.doi.org/10.1155/2013/852093 Text en Copyright © 2013 Angélica M. Gomes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gomes, Angélica M.
Stelling, Mariana P.
Pavão, Mauro S. G.
Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
title Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
title_full Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
title_fullStr Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
title_full_unstemmed Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
title_short Heparan Sulfate and Heparanase as Modulators of Breast Cancer Progression
title_sort heparan sulfate and heparanase as modulators of breast cancer progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747466/
https://www.ncbi.nlm.nih.gov/pubmed/23984412
http://dx.doi.org/10.1155/2013/852093
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