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A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β-Lactam Stress
A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of endogenous reactive oxygen species (ROS), a process requiring the citric acid cycle (tricarboxylic acid [TCA] cycle). To test this hypothesis, we assessed the ability of oxacillin to i...
Autores principales: | Chittezham Thomas, Vinai, Kinkead, Lauren C., Janssen, Ashley, Schaeffer, Carolyn R., Woods, Keith M., Lindgren, Jill K., Peaster, Jonathan M., Chaudhari, Sujata S., Sadykov, Marat, Jones, Joselyn, Mohamadi AbdelGhani, Sameh M., Zimmerman, Matthew C., Bayles, Kenneth W., Somerville, Greg A., Fey, Paul D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747581/ https://www.ncbi.nlm.nih.gov/pubmed/23963176 http://dx.doi.org/10.1128/mBio.00437-13 |
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