A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β-Lactam Stress

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A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of endogenous reactive oxygen species (ROS), a process requiring the citric acid cycle (tricarboxylic acid [TCA] cycle). To test this hypothesis, we assessed the ability of oxacillin to i...

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Detalles Bibliográficos
Autores principales: Chittezham Thomas, Vinai, Kinkead, Lauren C., Janssen, Ashley, Schaeffer, Carolyn R., Woods, Keith M., Lindgren, Jill K., Peaster, Jonathan M., Chaudhari, Sujata S., Sadykov, Marat, Jones, Joselyn, Mohamadi AbdelGhani, Sameh M., Zimmerman, Matthew C., Bayles, Kenneth W., Somerville, Greg A., Fey, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747581/
https://www.ncbi.nlm.nih.gov/pubmed/23963176
http://dx.doi.org/10.1128/mBio.00437-13
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