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Peptides’ role in autism with emphasis on exorphins

PROBLEM: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. METHODS: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid–acetonitril gradients. Peaks eluting where synthetic opi...

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Autores principales: Reichelt, Karl L., Tveiten, Dag, Knivsberg, Anne-Mari, Brønstad, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747763/
https://www.ncbi.nlm.nih.gov/pubmed/23990835
http://dx.doi.org/10.3402/mehd.v23i0.18958
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author Reichelt, Karl L.
Tveiten, Dag
Knivsberg, Anne-Mari
Brønstad, Gunnar
author_facet Reichelt, Karl L.
Tveiten, Dag
Knivsberg, Anne-Mari
Brønstad, Gunnar
author_sort Reichelt, Karl L.
collection PubMed
description PROBLEM: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. METHODS: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid–acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer. RESULTS: We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next. CONCLUSION: Exorphins are found in urine of autistic children and may account for their symptoms.
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spelling pubmed-37477632013-08-29 Peptides’ role in autism with emphasis on exorphins Reichelt, Karl L. Tveiten, Dag Knivsberg, Anne-Mari Brønstad, Gunnar Microb Ecol Health Dis Thematic Cluster: Focus on Autism Spectrum Disorders PROBLEM: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. METHODS: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid–acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer. RESULTS: We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next. CONCLUSION: Exorphins are found in urine of autistic children and may account for their symptoms. Co-Action Publishing 2012-08-24 /pmc/articles/PMC3747763/ /pubmed/23990835 http://dx.doi.org/10.3402/mehd.v23i0.18958 Text en © 2012 K.L. Reichelt et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Thematic Cluster: Focus on Autism Spectrum Disorders
Reichelt, Karl L.
Tveiten, Dag
Knivsberg, Anne-Mari
Brønstad, Gunnar
Peptides’ role in autism with emphasis on exorphins
title Peptides’ role in autism with emphasis on exorphins
title_full Peptides’ role in autism with emphasis on exorphins
title_fullStr Peptides’ role in autism with emphasis on exorphins
title_full_unstemmed Peptides’ role in autism with emphasis on exorphins
title_short Peptides’ role in autism with emphasis on exorphins
title_sort peptides’ role in autism with emphasis on exorphins
topic Thematic Cluster: Focus on Autism Spectrum Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747763/
https://www.ncbi.nlm.nih.gov/pubmed/23990835
http://dx.doi.org/10.3402/mehd.v23i0.18958
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