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Peptides’ role in autism with emphasis on exorphins
PROBLEM: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. METHODS: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid–acetonitril gradients. Peaks eluting where synthetic opi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747763/ https://www.ncbi.nlm.nih.gov/pubmed/23990835 http://dx.doi.org/10.3402/mehd.v23i0.18958 |
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author | Reichelt, Karl L. Tveiten, Dag Knivsberg, Anne-Mari Brønstad, Gunnar |
author_facet | Reichelt, Karl L. Tveiten, Dag Knivsberg, Anne-Mari Brønstad, Gunnar |
author_sort | Reichelt, Karl L. |
collection | PubMed |
description | PROBLEM: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. METHODS: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid–acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer. RESULTS: We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next. CONCLUSION: Exorphins are found in urine of autistic children and may account for their symptoms. |
format | Online Article Text |
id | pubmed-3747763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-37477632013-08-29 Peptides’ role in autism with emphasis on exorphins Reichelt, Karl L. Tveiten, Dag Knivsberg, Anne-Mari Brønstad, Gunnar Microb Ecol Health Dis Thematic Cluster: Focus on Autism Spectrum Disorders PROBLEM: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. METHODS: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid–acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer. RESULTS: We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next. CONCLUSION: Exorphins are found in urine of autistic children and may account for their symptoms. Co-Action Publishing 2012-08-24 /pmc/articles/PMC3747763/ /pubmed/23990835 http://dx.doi.org/10.3402/mehd.v23i0.18958 Text en © 2012 K.L. Reichelt et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Thematic Cluster: Focus on Autism Spectrum Disorders Reichelt, Karl L. Tveiten, Dag Knivsberg, Anne-Mari Brønstad, Gunnar Peptides’ role in autism with emphasis on exorphins |
title | Peptides’ role in autism with emphasis on exorphins |
title_full | Peptides’ role in autism with emphasis on exorphins |
title_fullStr | Peptides’ role in autism with emphasis on exorphins |
title_full_unstemmed | Peptides’ role in autism with emphasis on exorphins |
title_short | Peptides’ role in autism with emphasis on exorphins |
title_sort | peptides’ role in autism with emphasis on exorphins |
topic | Thematic Cluster: Focus on Autism Spectrum Disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747763/ https://www.ncbi.nlm.nih.gov/pubmed/23990835 http://dx.doi.org/10.3402/mehd.v23i0.18958 |
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