Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation

A pathological hallmark of Alzheimer’s disease (AD) is the presence of amyloid-beta peptide (Aβ) plaques in the brain. Aβ is derived from a sequential proteolysis of the transmenbrane amyloid precursor protein (APP), a process which is dependent on the distribution of lipids present in the plasma me...

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Detalles Bibliográficos
Autores principales: Hsiao, Jen-Hsiang T., Fu, YuHong, Hill, Andrew F., Halliday, Glenda M., Kim, Woojin Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748018/
https://www.ncbi.nlm.nih.gov/pubmed/23977395
http://dx.doi.org/10.1371/journal.pone.0074016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748018/
https://www.ncbi.nlm.nih.gov/pubmed/23977395
http://dx.doi.org/10.1371/journal.pone.0074016

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