Cargando…

HEXIM1 Induces Differentiation of Human Pluripotent Stem Cells

Hexamethylene bisacetamide inducible protein 1 (HEXIM1) is best known as the inhibitor of positive transcription elongation factor b (P-TEFb), which is composed of cyclin-dependent kinase 9 (CDK9)/cyclin T1. P-TEFb is an essential regulator for the transcriptional elongation by RNA polymerase II. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ding, Vanessa, Lew, Qiao Jing, Chu, Kai Ling, Natarajan, Subaashini, Rajasegaran, Vikneswari, Gurumurthy, Meera, Choo, Andre B. H., Chao, Sheng-Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748041/ https://www.ncbi.nlm.nih.gov/pubmed/23977357 http://dx.doi.org/10.1371/journal.pone.0072823

Ejemplares similares

HEXIM1, a New Player in the p53 Pathway
por: Lew, Qiao Jing, et al.
Publicado: (2013)

PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
por: Lew, Qiao Jing, et al.
Publicado: (2011)

Brd4 and HEXIM1: Multiple Roles in P-TEFb Regulation and Cancer
por: Chen, Ruichuan, et al.
Publicado: (2014)

Use of a novel cytotoxic HEXIM1 peptide in the directed breast cancer therapy
por: Neo, Shu Hui, et al.
Publicado: (2015)

Inhibition of Tat activity by the HEXIM1 protein
por: Fraldi, Alessandro, et al.
Publicado: (2005)

HEXIM1 is a critical determinant of the response to tamoxifen
por: Ketchart, Wannarasmi, et al.
Publicado: (2011)

PKC phosphorylates HEXIM1 and regulates P-TEFb activity
por: Fujinaga, Koh, et al.
Publicado: (2012)

HEXIM1-Tat chimera inhibits HIV-1 replication
por: Leoz, Marie, et al.
Publicado: (2018)

Tyrosine Phosphorylation Profiling in FGF-2 Stimulated Human Embryonic Stem Cells
por: Ding, Vanessa M. Y., et al.
Publicado: (2011)

Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts
por: Yu, Wei-Ping, et al.
Publicado: (2007)

Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis
por: Ketchart, Wannarasmi, et al.
Publicado: (2012)

The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells
por: Munoz, Javier, et al.
Publicado: (2011)

HEXIM1 Peptide Exhibits Antimicrobial Activity Against Antibiotic Resistant Bacteria Through Guidance of Cell Penetrating Peptide
por: Ho, Pooi Leng, et al.
Publicado: (2019)

The Drosophila 7SK snRNP and the essential role of dHEXIM in development
por: Nguyen, Duy, et al.
Publicado: (2012)

Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development
por: Nguyen, Duy, et al.
Publicado: (2016)

Structural transitions in the RNA 7SK 5′ hairpin and their effect on HEXIM binding
por: Röder, Konstantin, et al.
Publicado: (2020)

Non-epigenetic induction of HEXIM1 by DNMT1 inhibitors and functional relevance
por: Sharma, Vikas, et al.
Publicado: (2020)

CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors
por: Lloyd, Sarah M., et al.
Publicado: (2022)

Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells
por: Ihnatovych, Ivanna, et al.
Publicado: (2018)

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription
por: Barboric, Matjaz, et al.
Publicado: (2007)

BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
por: Bowry, Akhil, et al.
Publicado: (2018)

Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells
por: Huang, Min, et al.
Publicado: (2016)

HEXIM1 Diffusion in the Nucleus Is Regulated by Its Interactions with Both 7SK and P-TEFb
por: Furlan, Alessandro, et al.
Publicado: (2019)

Opportunities for Antibody Discovery Using Human Pluripotent Stem Cells: Conservation of Oncofetal Targets
por: Tan, Heng Liang, et al.
Publicado: (2019)

Bovine HEXIM1 inhibits bovine immunodeficiency virus replication through regulating BTat-mediated transactivation
por: Guo, Hong-yan, et al.
Publicado: (2013)

HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist
por: Devaraj, Santhana G. T., et al.
Publicado: (2015)

HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer
por: Shao, Hengyi, et al.
Publicado: (2020)

A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA
por: Pham, Vincent V., et al.
Publicado: (2022)

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells
por: Ang, Lay Teng, et al.
Publicado: (2018)

Enhancing myogenic differentiation of pluripotent stem cells with small molecule inducers
por: Chen, Jihong, et al.
Publicado: (2013)

Cardiac Differentiation of Pluripotent Stem Cells
por: Rajala, Kristiina, et al.
Publicado: (2011)

HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland
por: Ogba, Ndiya, et al.
Publicado: (2010)

Cardiomyocyte-Specific Overexpression of HEXIM1 Prevents Right Ventricular Hypertrophy in Hypoxia-Induced Pulmonary Hypertension in Mice
por: Yoshikawa, Noritada, et al.
Publicado: (2012)

Nanobiosensing Platforms for Real-Time and Non-Invasive Monitoring of Stem Cell Pluripotency and Differentiation
por: Suhito, Intan Rosalina, et al.
Publicado: (2018)

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb
por: Blazek, Dalibor, et al.
Publicado: (2005)

HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements
por: Lebars, Isabelle, et al.
Publicado: (2010)

Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells
por: Han, Liping, et al.
Publicado: (2017)

Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells
por: Lukovic, Dunja, et al.
Publicado: (2014)

Murine pluripotent stem cells that escape differentiation inside teratomas maintain pluripotency
por: Pei, Yangli, et al.
Publicado: (2018)

Cardiac differentiation of human pluripotent stem cells
por: Jiang, Junjie, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_albn6tni3i9sijo0knp0db8s4m