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Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory

The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by p...

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Autores principales: Matsunaga, Masahiro, Bai, Yu, Yamakawa, Kaori, Toyama, Asako, Kashiwagi, Mitsuyoshi, Fukuda, Kazuyuki, Oshida, Akiko, Sanada, Kazue, Fukuyama, Seisuke, Shinoda, Jun, Yamada, Jitsuhiro, Sadato, Norihiro, Ohira, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748042/
https://www.ncbi.nlm.nih.gov/pubmed/23977312
http://dx.doi.org/10.1371/journal.pone.0072523
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author Matsunaga, Masahiro
Bai, Yu
Yamakawa, Kaori
Toyama, Asako
Kashiwagi, Mitsuyoshi
Fukuda, Kazuyuki
Oshida, Akiko
Sanada, Kazue
Fukuyama, Seisuke
Shinoda, Jun
Yamada, Jitsuhiro
Sadato, Norihiro
Ohira, Hideki
author_facet Matsunaga, Masahiro
Bai, Yu
Yamakawa, Kaori
Toyama, Asako
Kashiwagi, Mitsuyoshi
Fukuda, Kazuyuki
Oshida, Akiko
Sanada, Kazue
Fukuyama, Seisuke
Shinoda, Jun
Yamada, Jitsuhiro
Sadato, Norihiro
Ohira, Hideki
author_sort Matsunaga, Masahiro
collection PubMed
description The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by positive emotions has remarkable effects on various psychological and physiological activities, including the secretion of cytokines, which are immune-signaling molecules that modulate systemic inflammation. In this study, we aimed to clarify the neural substrates associated with the interaction between odor-evoked autobiographic memory and peripheral circulating cytokines. We recruited healthy male and female volunteers and investigated the association between brain responses and the concentration of several cytokines in the plasma by using positron emission tomography (PET) recordings when an autographic memory was evoked in participants by asking them to smell an odor that was nostalgic to them. Participants experienced positive emotions and autobiographic memories when nostalgic odors were presented to them. The levels of peripheral proinflammatory cytokines, such as the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), were significantly reduced after experiencing odor-evoked autobiographic memory. Subtraction analysis of PET images indicated that the medial orbitofrontal cortex (mOFC) and precuneus/posterior cingulate cortex (PCC) were significantly activated during experiences of odor-evoked autobiographic memory. Furthermore, a correlation analysis indicated that activities of the mOFC and precuneus/PCC were negatively correlated with IFN-γ concentration. These results indicate that the neural networks including the precuneus/PCC and mOFC might regulate the secretion of peripheral proinflammatory cytokines during the experience of odor-evoked autobiographic memories accompanied with positive emotions.
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spelling pubmed-37480422013-08-23 Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory Matsunaga, Masahiro Bai, Yu Yamakawa, Kaori Toyama, Asako Kashiwagi, Mitsuyoshi Fukuda, Kazuyuki Oshida, Akiko Sanada, Kazue Fukuyama, Seisuke Shinoda, Jun Yamada, Jitsuhiro Sadato, Norihiro Ohira, Hideki PLoS One Research Article The phenomenon in which a certain smell evokes a specific memory is known as the Proust phenomenon. Odor-evoked autobiographic memories are more emotional than those elicited by other sensory stimuli. The results of our previous study indicated that odor-evoked autobiographic memory accompanied by positive emotions has remarkable effects on various psychological and physiological activities, including the secretion of cytokines, which are immune-signaling molecules that modulate systemic inflammation. In this study, we aimed to clarify the neural substrates associated with the interaction between odor-evoked autobiographic memory and peripheral circulating cytokines. We recruited healthy male and female volunteers and investigated the association between brain responses and the concentration of several cytokines in the plasma by using positron emission tomography (PET) recordings when an autographic memory was evoked in participants by asking them to smell an odor that was nostalgic to them. Participants experienced positive emotions and autobiographic memories when nostalgic odors were presented to them. The levels of peripheral proinflammatory cytokines, such as the tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), were significantly reduced after experiencing odor-evoked autobiographic memory. Subtraction analysis of PET images indicated that the medial orbitofrontal cortex (mOFC) and precuneus/posterior cingulate cortex (PCC) were significantly activated during experiences of odor-evoked autobiographic memory. Furthermore, a correlation analysis indicated that activities of the mOFC and precuneus/PCC were negatively correlated with IFN-γ concentration. These results indicate that the neural networks including the precuneus/PCC and mOFC might regulate the secretion of peripheral proinflammatory cytokines during the experience of odor-evoked autobiographic memories accompanied with positive emotions. Public Library of Science 2013-08-20 /pmc/articles/PMC3748042/ /pubmed/23977312 http://dx.doi.org/10.1371/journal.pone.0072523 Text en © 2013 Matsunaga et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Matsunaga, Masahiro
Bai, Yu
Yamakawa, Kaori
Toyama, Asako
Kashiwagi, Mitsuyoshi
Fukuda, Kazuyuki
Oshida, Akiko
Sanada, Kazue
Fukuyama, Seisuke
Shinoda, Jun
Yamada, Jitsuhiro
Sadato, Norihiro
Ohira, Hideki
Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory
title Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory
title_full Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory
title_fullStr Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory
title_full_unstemmed Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory
title_short Brain–Immune Interaction Accompanying Odor-Evoked Autobiographic Memory
title_sort brain–immune interaction accompanying odor-evoked autobiographic memory
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748042/
https://www.ncbi.nlm.nih.gov/pubmed/23977312
http://dx.doi.org/10.1371/journal.pone.0072523
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