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Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats

Fluorene is one of the most abundant polycyclic aromatic hydrocarbons in air and may contribute to the neurobehavioral alterations induced by the environmental exposure of humans to PAHs. Since no data are available on fluorene neurotoxicity, this study was conducted in adult rats to assess the beha...

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Autores principales: Peiffer, Julie, Cosnier, Frédéric, Grova, Nathalie, Nunge, Hervé, Salquèbre, Guillaume, Decret, Marie-Josèphe, Cossec, Benoît, Rychen, Guido, Appenzeller, Brice M. R., Schroeder, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748071/
https://www.ncbi.nlm.nih.gov/pubmed/23977039
http://dx.doi.org/10.1371/journal.pone.0071413
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author Peiffer, Julie
Cosnier, Frédéric
Grova, Nathalie
Nunge, Hervé
Salquèbre, Guillaume
Decret, Marie-Josèphe
Cossec, Benoît
Rychen, Guido
Appenzeller, Brice M. R.
Schroeder, Henri
author_facet Peiffer, Julie
Cosnier, Frédéric
Grova, Nathalie
Nunge, Hervé
Salquèbre, Guillaume
Decret, Marie-Josèphe
Cossec, Benoît
Rychen, Guido
Appenzeller, Brice M. R.
Schroeder, Henri
author_sort Peiffer, Julie
collection PubMed
description Fluorene is one of the most abundant polycyclic aromatic hydrocarbons in air and may contribute to the neurobehavioral alterations induced by the environmental exposure of humans to PAHs. Since no data are available on fluorene neurotoxicity, this study was conducted in adult rats to assess the behavioral toxicity of repeated fluorene inhalation exposure. Male rats (n = 18/group) were exposed nose-only to 1.5 or 150 ppb of fluorene 6 hours/day for 14 consecutive days, whereas the control animals were exposed to non-contaminated air. At the end of the exposure, animals were tested for activity and anxiety in an open-field and in an elevated-plus maze, for short-term memory in a Y-maze, and for spatial learning in an eight-arm maze. The results showed that the locomotor activity and the learning performances of the animals were unaffected by fluorene. In parallel, the fluorene-exposed rats showed a lower level of anxiety than controls in the open-field, but not in the elevated-plus maze, which is probably due to a possible difference in the aversive feature of the two mazes. In the same animals, increasing blood and brain levels of fluorene monohydroxylated metabolites (especially the 2-OH fluorene) were detected at both concentrations (1.5 and 150 ppb), demonstrating the exposure of the animals to the pollutant and showing the ability of this compound to be metabolized and to reach the cerebral compartment. The present study highlights the possibility for a 14-day fluorene exposure to induce some specific anxiety-related behavioral disturbances, and argues in favor of the susceptibility of the adult brain when exposed to volatile fluorene.
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spelling pubmed-37480712013-08-23 Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats Peiffer, Julie Cosnier, Frédéric Grova, Nathalie Nunge, Hervé Salquèbre, Guillaume Decret, Marie-Josèphe Cossec, Benoît Rychen, Guido Appenzeller, Brice M. R. Schroeder, Henri PLoS One Research Article Fluorene is one of the most abundant polycyclic aromatic hydrocarbons in air and may contribute to the neurobehavioral alterations induced by the environmental exposure of humans to PAHs. Since no data are available on fluorene neurotoxicity, this study was conducted in adult rats to assess the behavioral toxicity of repeated fluorene inhalation exposure. Male rats (n = 18/group) were exposed nose-only to 1.5 or 150 ppb of fluorene 6 hours/day for 14 consecutive days, whereas the control animals were exposed to non-contaminated air. At the end of the exposure, animals were tested for activity and anxiety in an open-field and in an elevated-plus maze, for short-term memory in a Y-maze, and for spatial learning in an eight-arm maze. The results showed that the locomotor activity and the learning performances of the animals were unaffected by fluorene. In parallel, the fluorene-exposed rats showed a lower level of anxiety than controls in the open-field, but not in the elevated-plus maze, which is probably due to a possible difference in the aversive feature of the two mazes. In the same animals, increasing blood and brain levels of fluorene monohydroxylated metabolites (especially the 2-OH fluorene) were detected at both concentrations (1.5 and 150 ppb), demonstrating the exposure of the animals to the pollutant and showing the ability of this compound to be metabolized and to reach the cerebral compartment. The present study highlights the possibility for a 14-day fluorene exposure to induce some specific anxiety-related behavioral disturbances, and argues in favor of the susceptibility of the adult brain when exposed to volatile fluorene. Public Library of Science 2013-08-20 /pmc/articles/PMC3748071/ /pubmed/23977039 http://dx.doi.org/10.1371/journal.pone.0071413 Text en © 2013 Peiffer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Peiffer, Julie
Cosnier, Frédéric
Grova, Nathalie
Nunge, Hervé
Salquèbre, Guillaume
Decret, Marie-Josèphe
Cossec, Benoît
Rychen, Guido
Appenzeller, Brice M. R.
Schroeder, Henri
Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats
title Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats
title_full Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats
title_fullStr Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats
title_full_unstemmed Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats
title_short Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats
title_sort neurobehavioral toxicity of a repeated exposure (14 days) to the airborne polycyclic aromatic hydrocarbon fluorene in adult wistar male rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748071/
https://www.ncbi.nlm.nih.gov/pubmed/23977039
http://dx.doi.org/10.1371/journal.pone.0071413
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