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FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma
Forkhead box protein P3 (FOXP3) expression in tumor infiltrating CD4(+)T cells is generally associated with an intrinsic capacity to suppress tumor immunity. Based on this notion, different studies have evaluated the prognostic value of this maker in cancer but contradictory results have been found....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748098/ https://www.ncbi.nlm.nih.gov/pubmed/23977174 http://dx.doi.org/10.1371/journal.pone.0071908 |
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author | Weed, Donald T. Walker, Gail De La Fuente, Adriana C. Nazarian, Ronen Vella, Jennifer L. Gomez-Fernandez, Carmen R. Serafini, Paolo |
author_facet | Weed, Donald T. Walker, Gail De La Fuente, Adriana C. Nazarian, Ronen Vella, Jennifer L. Gomez-Fernandez, Carmen R. Serafini, Paolo |
author_sort | Weed, Donald T. |
collection | PubMed |
description | Forkhead box protein P3 (FOXP3) expression in tumor infiltrating CD4(+)T cells is generally associated with an intrinsic capacity to suppress tumor immunity. Based on this notion, different studies have evaluated the prognostic value of this maker in cancer but contradictory results have been found. Indeed, even within the same cancer population, the presence of CD4(+)FOXP3(+)T cells has been associated,with either a poor or a good prognosis, or no correlation has beenfound. Here, we demonstrate,in patients with oral squamous cell carcinoma (OSCC), that what really represents a prognostic parameter is not the overall expression of FOXP3 but its intracellular localization.While overallFOXP3 expression in tumor infiltrating CD4(+)T cells does not correlate with tumor recurrence, its intracellular localization within the CD4 cells does: nuclear FOXP3 (nFOXP3) is associated with tumor recurrence within 3 years, while cytoplasmicFOXP3 (cFOXP3) is associated with a lower likelihood of recurrence. Thus, we propose elevated levels of the cFOXP3/nFOXP3 ratio within tumor infiltrating CD4(+) T cells as a predictor of OSCC recurrence. |
format | Online Article Text |
id | pubmed-3748098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37480982013-08-23 FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma Weed, Donald T. Walker, Gail De La Fuente, Adriana C. Nazarian, Ronen Vella, Jennifer L. Gomez-Fernandez, Carmen R. Serafini, Paolo PLoS One Research Article Forkhead box protein P3 (FOXP3) expression in tumor infiltrating CD4(+)T cells is generally associated with an intrinsic capacity to suppress tumor immunity. Based on this notion, different studies have evaluated the prognostic value of this maker in cancer but contradictory results have been found. Indeed, even within the same cancer population, the presence of CD4(+)FOXP3(+)T cells has been associated,with either a poor or a good prognosis, or no correlation has beenfound. Here, we demonstrate,in patients with oral squamous cell carcinoma (OSCC), that what really represents a prognostic parameter is not the overall expression of FOXP3 but its intracellular localization.While overallFOXP3 expression in tumor infiltrating CD4(+)T cells does not correlate with tumor recurrence, its intracellular localization within the CD4 cells does: nuclear FOXP3 (nFOXP3) is associated with tumor recurrence within 3 years, while cytoplasmicFOXP3 (cFOXP3) is associated with a lower likelihood of recurrence. Thus, we propose elevated levels of the cFOXP3/nFOXP3 ratio within tumor infiltrating CD4(+) T cells as a predictor of OSCC recurrence. Public Library of Science 2013-08-20 /pmc/articles/PMC3748098/ /pubmed/23977174 http://dx.doi.org/10.1371/journal.pone.0071908 Text en © 2013 Weed et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Weed, Donald T. Walker, Gail De La Fuente, Adriana C. Nazarian, Ronen Vella, Jennifer L. Gomez-Fernandez, Carmen R. Serafini, Paolo FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma |
title | FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma |
title_full | FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma |
title_fullStr | FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma |
title_full_unstemmed | FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma |
title_short | FOXP3 Subcellular Localization Predicts Recurrence in Oral Squamous Cell Carcinoma |
title_sort | foxp3 subcellular localization predicts recurrence in oral squamous cell carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748098/ https://www.ncbi.nlm.nih.gov/pubmed/23977174 http://dx.doi.org/10.1371/journal.pone.0071908 |
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