Characterization of FKGK18 as Inhibitor of Group VIA Ca(2+)-Independent Phospholipase A(2) (iPLA(2)β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes

Ongoing studies suggest an important role for iPLA(2)β in a multitude of biological processes and it has been implicated in neurodegenerative, skeletal and vascular smooth muscle disorders, bone formation, and cardiac arrhythmias. Thus, identifying an iPLA(2)βinhibitor that can be reliably and safel...

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Detalles Bibliográficos
Autores principales: Ali, Tomader, Kokotos, George, Magrioti, Victoria, Bone, Robert N., Mobley, James A., Hancock, William, Ramanadham, Sasanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748103/
https://www.ncbi.nlm.nih.gov/pubmed/23977134
http://dx.doi.org/10.1371/journal.pone.0071748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748103/
https://www.ncbi.nlm.nih.gov/pubmed/23977134
http://dx.doi.org/10.1371/journal.pone.0071748

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