Direct uptake and degradation of DNA by lysosomes

Lysosomes contain various hydrolases that can degrade proteins, lipids, nucleic acids and carbohydrates. We recently discovered “RNautophagy,” an autophagic pathway in which RNA is directly taken up by lysosomes and degraded. A lysosomal membrane protein, LAMP2C, a splice variant of LAMP2, binds to...

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Detalles Bibliográficos
Autores principales: Fujiwara, Yuuki, Kikuchi, Hisae, Aizawa, Shu, Furuta, Akiko, Hatanaka, Yusuke, Konya, Chiho, Uchida, Kenko, Wada, Keiji, Kabuta, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Basic Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748189/
https://www.ncbi.nlm.nih.gov/pubmed/23839276
http://dx.doi.org/10.4161/auto.24880

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