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The initiation of mammalian protein synthesis and the mechanism of scanning
During translation initiation in eukaryotes, the small ribosomal subunit binds mRNA at the 5′-end and scans in the 5′ to 3′ direction to locate the initiation codon, form the 80S initiation complex and start the protein synthesis. This simple, yet intricate, process is guided by multiple initiation...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748252/ https://www.ncbi.nlm.nih.gov/pubmed/23873042 http://dx.doi.org/10.1038/nature12355 |