Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells

The unfolded protein response (UPR) is an endoplasmic reticulum (ER)-based cytoprotective mechanism acting to prevent pathologies accompanying protein aggregation. It is frequently active in tumors, but relatively unstudied in gliomas. We hypothesized that UPR stress effects on glioma cells might pr...

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Detalles Bibliográficos
Autores principales: Epple, Laura M., Dodd, Rebecca D., Merz, Andrea L., Dechkovskaia, Anjelika M., Herring, Matthew, Winston, Benjamin A., Lencioni, Alex M., Russell, Rae L., Madsen, Helen, Nega, Meheret, Dusto, Nathaniel L., White, Jason, Bigner, Darell D., Nicchitta, Christopher V., Serkova, Natalie J., Graner, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748289/
https://www.ncbi.nlm.nih.gov/pubmed/24039668
http://dx.doi.org/10.1371/journal.pone.0073267

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