CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance

The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increa...

Descripción completa

Detalles Bibliográficos
Autores principales: Putz, Eva Maria, Gotthardt, Dagmar, Hoermann, Gregor, Csiszar, Agnes, Wirth, Silvia, Berger, Angelika, Straka, Elisabeth, Rigler, Doris, Wallner, Barbara, Jamieson, Amanda M., Pickl, Winfried F., Zebedin-Brandl, Eva Maria, Müller, Mathias, Decker, Thomas, Sexl, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748339/
https://www.ncbi.nlm.nih.gov/pubmed/23933255
http://dx.doi.org/10.1016/j.celrep.2013.07.012

Ejemplares similares

Ejemplares similares