RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication

Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for inn...

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Detalles Bibliográficos
Autores principales: Yamamoto, Yasuhiko, Yamamoto, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748367/
https://www.ncbi.nlm.nih.gov/pubmed/23970880
http://dx.doi.org/10.3389/fendo.2013.00105
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author Yamamoto, Yasuhiko
Yamamoto, Hiroshi
author_facet Yamamoto, Yasuhiko
Yamamoto, Hiroshi
author_sort Yamamoto, Yasuhiko
collection PubMed
description Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promoting inflammatory reactions. The receptor for advanced glycation end-products (RAGE) is a member of PRRs and a proinflammatory molecular device that mediates danger signals to the body. The expression of RAGE is observed in adipocytes as well as immune cells, endothelial cells, and pancreatic β cells under certain conditions. It has been reported that RAGE is implicated in adipocyte hypertrophy and insulin resistance. RAGE-mediated regulation of adiposity and inflammation may attribute to type 2 diabetes and diabetic vascular complications.
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spelling pubmed-37483672013-08-22 RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication Yamamoto, Yasuhiko Yamamoto, Hiroshi Front Endocrinol (Lausanne) Endocrinology Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promoting inflammatory reactions. The receptor for advanced glycation end-products (RAGE) is a member of PRRs and a proinflammatory molecular device that mediates danger signals to the body. The expression of RAGE is observed in adipocytes as well as immune cells, endothelial cells, and pancreatic β cells under certain conditions. It has been reported that RAGE is implicated in adipocyte hypertrophy and insulin resistance. RAGE-mediated regulation of adiposity and inflammation may attribute to type 2 diabetes and diabetic vascular complications. Frontiers Media S.A. 2013-08-21 /pmc/articles/PMC3748367/ /pubmed/23970880 http://dx.doi.org/10.3389/fendo.2013.00105 Text en Copyright © 2013 Yamamoto and Yamamoto. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yamamoto, Yasuhiko
Yamamoto, Hiroshi
RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication
title RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication
title_full RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication
title_fullStr RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication
title_full_unstemmed RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication
title_short RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication
title_sort rage-mediated inflammation, type 2 diabetes, and diabetic vascular complication
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748367/
https://www.ncbi.nlm.nih.gov/pubmed/23970880
http://dx.doi.org/10.3389/fendo.2013.00105
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AT yamamotohiroshi ragemediatedinflammationtype2diabetesanddiabeticvascularcomplication

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