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Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo
The flavolignan silibinin was studied for its ability to restore drug sensitivity to EGFR-mutant NSCLC xenografts with epithelial-to-mesenchymal transition (EMT)-driven resistance to erlotinib. As a single agent, silibinin significantly decreased the tumor volumes of erlotinib-refractory NSCLC xenog...
Autores principales: | Cufí, Sílvia, Bonavia, Rosa, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Corominas-Faja, Bruna, Cuyàs, Elisabet, Martin-Castillo, Begoña, Barrajón-Catalán, Enrique, Visa, Joana, Segura-Carretero, Antonio, Joven, Jorge, Bosch-Barrera, Joaquim, Micol, Vicente, Menendez, Javier A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748425/ https://www.ncbi.nlm.nih.gov/pubmed/23963283 http://dx.doi.org/10.1038/srep02459 |
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