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Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study

BACKGROUND: During the routine practice in the institution, it was observed that there were persistent incidents of inadequate/failed spinal anaesthesia in patients with a history of single or multiple scorpion bite/s. To test any possible correlation between scorpion bite and the altered response t...

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Autores principales: Panditrao, Mridul M, Panditrao, Minnu M, Sunilkumar, V, Panditrao, Aditi M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748676/
https://www.ncbi.nlm.nih.gov/pubmed/23983280
http://dx.doi.org/10.4103/0019-5049.115593
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author Panditrao, Mridul M
Panditrao, Minnu M
Sunilkumar, V
Panditrao, Aditi M
author_facet Panditrao, Mridul M
Panditrao, Minnu M
Sunilkumar, V
Panditrao, Aditi M
author_sort Panditrao, Mridul M
collection PubMed
description BACKGROUND: During the routine practice in the institution, it was observed that there were persistent incidents of inadequate/failed spinal anaesthesia in patients with a history of single or multiple scorpion bite/s. To test any possible correlation between scorpion bite and the altered response to spinal anaesthesia, a case control study was conducted involving patients with a history of scorpion bite/s and without such a history. METHODS: Randomly selected 70 (n=70) patients of either sex and age range of 18-80 years, were divided into two equal groups, giving past history of one or multiple scorpion bites and giving no such a history. The anaesthetic management was identical inclusive of subarachnoid block with 3.5 ml. 0.5% bupivacaine heavy. The onsets of sensory, motor and peaks of sensory and motor blocks were observed with the pin-prick method and Bromage scale. After waiting for 20 min, if the block was inadequate, then balanced general anaesthesia was administered. The analysis of the data and application of various statistical tests was carried out using Chi-square test, percentages, independent sample t-test and paired t-test. RESULTS: Demographically both groups were comparable. In scorpion bite group, the time of onsets of both sensory and motor blocks and time for the peak of sensory and motor blocks were significantly prolonged, 4 patients had failed/inadequate sensory block and 5 patients had failed/inadequate motor block while all the patients in non-bite group had adequate intra-operative block. CONCLUSION: We conclude that there appears to be a direct correlation between the histories of old, single or multiple scorpion bites and development of resistance to effect of local anaesthetics administered intra-thecally.
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spelling pubmed-37486762013-08-27 Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study Panditrao, Mridul M Panditrao, Minnu M Sunilkumar, V Panditrao, Aditi M Indian J Anaesth Clinical Investigation BACKGROUND: During the routine practice in the institution, it was observed that there were persistent incidents of inadequate/failed spinal anaesthesia in patients with a history of single or multiple scorpion bite/s. To test any possible correlation between scorpion bite and the altered response to spinal anaesthesia, a case control study was conducted involving patients with a history of scorpion bite/s and without such a history. METHODS: Randomly selected 70 (n=70) patients of either sex and age range of 18-80 years, were divided into two equal groups, giving past history of one or multiple scorpion bites and giving no such a history. The anaesthetic management was identical inclusive of subarachnoid block with 3.5 ml. 0.5% bupivacaine heavy. The onsets of sensory, motor and peaks of sensory and motor blocks were observed with the pin-prick method and Bromage scale. After waiting for 20 min, if the block was inadequate, then balanced general anaesthesia was administered. The analysis of the data and application of various statistical tests was carried out using Chi-square test, percentages, independent sample t-test and paired t-test. RESULTS: Demographically both groups were comparable. In scorpion bite group, the time of onsets of both sensory and motor blocks and time for the peak of sensory and motor blocks were significantly prolonged, 4 patients had failed/inadequate sensory block and 5 patients had failed/inadequate motor block while all the patients in non-bite group had adequate intra-operative block. CONCLUSION: We conclude that there appears to be a direct correlation between the histories of old, single or multiple scorpion bites and development of resistance to effect of local anaesthetics administered intra-thecally. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3748676/ /pubmed/23983280 http://dx.doi.org/10.4103/0019-5049.115593 Text en Copyright: © Indian Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Panditrao, Mridul M
Panditrao, Minnu M
Sunilkumar, V
Panditrao, Aditi M
Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study
title Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study
title_full Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study
title_fullStr Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study
title_full_unstemmed Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study
title_short Effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: A case control study
title_sort effect of previous scorpion bite(s) on the action of intrathecal bupivacaine: a case control study
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748676/
https://www.ncbi.nlm.nih.gov/pubmed/23983280
http://dx.doi.org/10.4103/0019-5049.115593
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