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Dexmedetomidine overdosage: An unusual presentation

We present a case of dexmedetomidine toxicity in a 3-year-old child. The case report describes the features and outlines the treatment strategy adopted. The child presented with bradypnoea, bradycardia, hypotension, deep hypnosis and miosis. He was successfully managed with oxygen, saline boluses an...

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Detalles Bibliográficos
Autores principales: Nath, Soumya S, Singh, Sujan, Pawar, Sundeep T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748686/
https://www.ncbi.nlm.nih.gov/pubmed/23983290
http://dx.doi.org/10.4103/0019-5049.115617
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author Nath, Soumya S
Singh, Sujan
Pawar, Sundeep T
author_facet Nath, Soumya S
Singh, Sujan
Pawar, Sundeep T
author_sort Nath, Soumya S
collection PubMed
description We present a case of dexmedetomidine toxicity in a 3-year-old child. The case report describes the features and outlines the treatment strategy adopted. The child presented with bradypnoea, bradycardia, hypotension, deep hypnosis and miosis. He was successfully managed with oxygen, saline boluses and adrenaline infusion. He became haemodynamically stable with adrenaline infusion. He started responding to painful stimuli in 3 h and became oriented in 7 h. Dexmedetomidine, a selective α(2) adrenoceptor agonist, is claimed to have a wide safety margin. This case report highlights the fact that dexmedetomidine administered in a toxic dose may be life-threatening may present with miosis and adrenaline infusion may be a useful supportive treatment.
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spelling pubmed-37486862013-08-27 Dexmedetomidine overdosage: An unusual presentation Nath, Soumya S Singh, Sujan Pawar, Sundeep T Indian J Anaesth Case Report We present a case of dexmedetomidine toxicity in a 3-year-old child. The case report describes the features and outlines the treatment strategy adopted. The child presented with bradypnoea, bradycardia, hypotension, deep hypnosis and miosis. He was successfully managed with oxygen, saline boluses and adrenaline infusion. He became haemodynamically stable with adrenaline infusion. He started responding to painful stimuli in 3 h and became oriented in 7 h. Dexmedetomidine, a selective α(2) adrenoceptor agonist, is claimed to have a wide safety margin. This case report highlights the fact that dexmedetomidine administered in a toxic dose may be life-threatening may present with miosis and adrenaline infusion may be a useful supportive treatment. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3748686/ /pubmed/23983290 http://dx.doi.org/10.4103/0019-5049.115617 Text en Copyright: © Indian Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nath, Soumya S
Singh, Sujan
Pawar, Sundeep T
Dexmedetomidine overdosage: An unusual presentation
title Dexmedetomidine overdosage: An unusual presentation
title_full Dexmedetomidine overdosage: An unusual presentation
title_fullStr Dexmedetomidine overdosage: An unusual presentation
title_full_unstemmed Dexmedetomidine overdosage: An unusual presentation
title_short Dexmedetomidine overdosage: An unusual presentation
title_sort dexmedetomidine overdosage: an unusual presentation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748686/
https://www.ncbi.nlm.nih.gov/pubmed/23983290
http://dx.doi.org/10.4103/0019-5049.115617
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