Cargando…

Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS

BACKGROUND: HIV infection persists despite antiretroviral treatment (ART) and is reignited as soon as therapies are suspended. This vicious cycle is fueled by the persistence of viral reservoirs that are invulnerable to standard ART protocols, and thus therapeutic agents able to target these reservo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shytaj, Iart Luca, Chirullo, Barbara, Wagner, Wendeline, Ferrari, Maria G, Sgarbanti, Rossella, Corte, Alessandro Della, LaBranche, Celia, Lopalco, Lucia, Palamara, Anna Teresa, Montefiori, David, Lewis, Mark G, Garaci, Enrico, Savarino, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748827/ https://www.ncbi.nlm.nih.gov/pubmed/23866829 http://dx.doi.org/10.1186/1742-4690-10-71

Ejemplares similares

A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model
por: Shytaj, Iart Luca, et al.
Publicado: (2012)

A cure for AIDS: a matter of timing?
por: Shytaj, Iart Luca, et al.
Publicado: (2013)

Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS
por: Savarino, Andrea, et al.
Publicado: (2015)

Modified Newcastle Disease virus as an improved vaccine vector against Simian Immunodeficiency virus
por: Manoharan, Vinoth K., et al.
Publicado: (2018)

A candidate anti-HIV reservoir compound, auranofin, exerts a selective ‘anti-memory' effect by exploiting the baseline oxidative status of lymphocytes
por: Chirullo, B, et al.
Publicado: (2013)

Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy
por: Lewis, Mark G, et al.
Publicado: (2010)

Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques
por: Lewis, MG, et al.
Publicado: (2010)

A scalable workflow to test “shock and kill” therapeutic approaches against the HIV-1 latent reservoir in blood cells ex vivo
por: Procopio, Francesco Andrea, et al.
Publicado: (2023)

Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques
por: Pahar, Bapi, et al.
Publicado: (2016)

Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
por: Savarino, Andrea, et al.
Publicado: (2012)

Interplay between Hepatitis C Virus and Redox Cell Signaling
por: Ruggieri, Anna, et al.
Publicado: (2013)

HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers
por: Capucci, Silvia, et al.
Publicado: (2017)

Correction: HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers
por: Capucci, Silvia, et al.
Publicado: (2023)

Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus Macaques
por: Pahar, Bapi, et al.
Publicado: (2022)

Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine
por: Chamcha, Venkateswarlu, et al.
Publicado: (2016)

The Environmental Pollutant Cadmium Promotes Influenza Virus Replication in MDCK Cells by Altering Their Redox State
por: Checconi, Paola, et al.
Publicado: (2013)

Infectious Agents and Neurodegeneration
por: De Chiara, Giovanna, et al.
Publicado: (2012)

Significant Depletion of CD4(+) T Cells Occurs in the Oral Mucosa during Simian Immunodeficiency Virus Infection with the Infected CD4(+) T Cell Reservoir Continuing to Persist in the Oral Mucosa during Antiretroviral Therapy
por: George, Jeffy, et al.
Publicado: (2015)

Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS
por: Amatore, Donatella, et al.
Publicado: (2015)

Mucosal Immunization with Newcastle Disease Virus Vector Coexpressing HIV-1 Env and Gag Proteins Elicits Potent Serum, Mucosal, and Cellular Immune Responses That Protect against Vaccinia Virus Env and Gag Challenges
por: Khattar, Sunil K., et al.
Publicado: (2015)

To rebound or not to rebound
por: Stahl, Bethany A, et al.
Publicado: (2017)

Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques
por: Rosenberg, Yvonne J., et al.
Publicado: (2016)

Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?
por: Sgarbanti, Rossella, et al.
Publicado: (2014)

Comparative Immunogenicity of HIV-1 gp160, gp140 and gp120 Expressed by Live Attenuated Newcastle Disease Virus Vector
por: Khattar, Sunil K., et al.
Publicado: (2013)

Correction: Comparative Immunogenicity of HIV-1 gp160, gp140 and gp120 Expressed by Live Attenuated Newcastle Disease Virus Vector
por: Khattar, Sunil K., et al.
Publicado: (2014)

Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers
por: Conway, Jessica M., et al.
Publicado: (2019)

Progress, pitfalls, and path forward of drug repurposing for COVID-19 treatment
por: Taibe, Noha Samir, et al.
Publicado: (2022)

Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine
por: Cai, Hui, et al.
Publicado: (2018)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2012)

Retraction: eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2014)

The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat
por: Montefiori, David C., et al.
Publicado: (2021)

Increased Proviral DNA in Circulating Cells Correlates with Plasma Viral Rebound in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Antiretroviral Therapy Interruption
por: Ziani, Widade, et al.
Publicado: (2021)

Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop
por: Qin, Yali, et al.
Publicado: (2015)

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques
por: Rosenberg, Yvonne J., et al.
Publicado: (2019)

Control of Heterologous Simian Immunodeficiency Virus SIV(smE660) Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques
por: Singh, Shakti, et al.
Publicado: (2018)

HIV transmitted/founder vaccines elicit autologous tier 2 neutralizing antibodies for the CD4 binding site
por: McCurley, Nathanael P., et al.
Publicado: (2017)

CTLA-4 Blockade, during HIV Virus-Like Particles Immunization, Alters HIV-Specific B-Cell Responses
por: Lewis, Phoebe E., et al.
Publicado: (2020)

Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques
por: Wahl-Jensen, Victoria, et al.
Publicado: (2016)

Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity.
por: Marini, S., et al.
Publicado: (1990)

Immunization of Rabbits with Highly Purified, Soluble, Trimeric Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Induces a Vigorous B Cell Response and Broadly Cross-Reactive Neutralization
por: Quinnan, Gerald V., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gujbht7q31ofai4v622dglptdi