Cargando…

Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence

Vaccinia virus (VACV) expresses many proteins that are non-essential for virus replication but promote virulence by inhibiting components of the host immune response to infection. These immunomodulators include a family of proteins that have, or are predicted to have, a structure related to the B-ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferguson, Brian J., Benfield, Camilla T. O., Ren, Hongwei, Lee, Vivian H., Frazer, Gordon L., Strnadova, Pavla, Sumner, Rebecca P., Smith, Geoffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for General Microbiology 2013
Materias:	Animal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749055/ https://www.ncbi.nlm.nih.gov/pubmed/23761407 http://dx.doi.org/10.1099/vir.0.054114-0

Ejemplares similares

Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection
por: Benfield, Camilla T. O., et al.
Publicado: (2013)

Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence
por: Ember, Stuart W. J., et al.
Publicado: (2012)

Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues
por: Maluquer de Motes, Carlos, et al.
Publicado: (2014)

Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy
por: Sumner, Rebecca P., et al.
Publicado: (2013)

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
por: Unterholzner, Leonie, et al.
Publicado: (2011)

Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence
por: Strnadova, Pavla, et al.
Publicado: (2015)

Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection
por: Veyer, David L., et al.
Publicado: (2014)

Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators
por: Sumner, Rebecca P., et al.
Publicado: (2016)

Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor
por: Ren, Hongwei, et al.
Publicado: (2015)

Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence
por: Mansur, Daniel S., et al.
Publicado: (2013)

Vaccinia virus B5 protein affects the glycosylation, localization and stability of the A34 protein
por: Breiman, Adrien, et al.
Publicado: (2010)

A role for vaccinia virus protein C16 in reprogramming cellular energy metabolism
por: Mazzon, Michela, et al.
Publicado: (2015)

Protein B5 is required on extracellular enveloped vaccinia virus for repulsion of superinfecting virions
por: Doceul, Virginie, et al.
Publicado: (2012)

Transport and stability of the vaccinia virus A34 protein is affected by the A33 protein
por: Breiman, Adrien, et al.
Publicado: (2013)

Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response
por: Froggatt, Graham C., et al.
Publicado: (2007)

Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3
por: Valentine, Robert, et al.
Publicado: (2010)

The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds
por: Gao, William N. D., et al.
Publicado: (2022)

Vaccinia virus strain NYVAC induces substantially lower and qualitatively different human antibody responses compared with strains Lister and Dryvax
por: Midgley, Claire M., et al.
Publicado: (2008)

Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection
por: Jacobs, Nathalie, et al.
Publicado: (2008)

Optimization of translation enhancing element use to increase protein expression in a vaccinia virus system
por: Richard Jr., Harold B., et al.
Publicado: (2021)

Vaccinia Virus Protein A49 Is an Unexpected Member of the B-cell Lymphoma (Bcl)-2 Protein Family
por: Neidel, Sarah, et al.
Publicado: (2015)

Acidic residues in the membrane-proximal stalk region of vaccinia virus protein B5 are required for glycosaminoglycan-mediated disruption of the extracellular enveloped virus outer membrane
por: Roberts, Kim L., et al.
Publicado: (2009)

Leaky scanning translation generates a second A49 protein that contributes to vaccinia virus virulence
por: Neidel, Sarah, et al.
Publicado: (2020)

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
por: Ferguson, Brian J, et al.
Publicado: (2012)

Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence
por: Gubser, Caroline, et al.
Publicado: (2007)

DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing
por: Scutts, Simon R., et al.
Publicado: (2018)

Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB
por: Benfield, Camilla T. O., et al.
Publicado: (2011)

Mutations in modified virus Ankara protein 183 render it a non-functional counterpart of B14, an inhibitor of nuclear factor κB activation
por: McCoy, Laura E., et al.
Publicado: (2010)

Bat and pig IFN-induced transmembrane protein 3 restrict cell entry by influenza virus and lyssaviruses
por: Benfield, Camilla T. O., et al.
Publicado: (2015)

Vaccinia Virus Inhibits NF-κB-Dependent Gene Expression Downstream of p65 Translocation
por: Sumner, Rebecca P., et al.
Publicado: (2014)

Enhanced Efficacy of Vaccination With Vaccinia Virus in Old vs. Young Mice
por: Shmeleva, Evgeniya V., et al.
Publicado: (2019)

Inhibition of IκB Kinase by Vaccinia Virus Virulence Factor B14
por: Chen, Ron A.-J, et al.
Publicado: (2008)

Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulence
por: Fahy, Aodhnait S., et al.
Publicado: (2008)

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2
por: Stuart, Jennifer H., et al.
Publicado: (2016)

Murine norovirus virulence factor 1 (VF1) protein contributes to viral fitness during persistent infection
por: Borg, Constantina, et al.
Publicado: (2021)

NSs of the mildly virulent sandfly fever Sicilian virus is unable to inhibit interferon signaling and upregulation of interferon-stimulated genes
por: Wuerth, Jennifer Deborah, et al.
Publicado: (2021)

Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins
por: Han, Soo-Jin, et al.
Publicado: (2010)

Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses
por: Hayasaka, Daisuke, et al.
Publicado: (2007)

Inner tegument protein pUL37 of herpes simplex virus type 1 is involved in directing capsids to the trans-Golgi network for envelopment
por: Pasdeloup, David, et al.
Publicado: (2010)

Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV
por: Depierreux, Delphine M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m46c361mp0pg1jormq3fff2lcm