Transforming Growth Factor-β–Induced Cross Talk Between p53 and a MicroRNA in the Pathogenesis of Diabetic Nephropathy

Elevated p53 expression is associated with several kidney diseases including diabetic nephropathy (DN). However, the mechanisms are unclear. We report that expression levels of transforming growth factor-β1 (TGF-β), p53, and microRNA-192 (miR-192) are increased in the renal cortex of diabetic mice,...

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Detalles Bibliográficos
Autores principales: Deshpande, Supriya D., Putta, Sumanth, Wang, Mei, Lai, Jennifer Y., Bitzer, Markus, Nelson, Robert G., Lanting, Linda L., Kato, Mitsuo, Natarajan, Rama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749352/
https://www.ncbi.nlm.nih.gov/pubmed/23649518
http://dx.doi.org/10.2337/db13-0305

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