The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway

The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances β-cell function. GLP-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, which inhibit the physiological inactivation of endogenous GLP-1, are used for the treatment of type 2 di...

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Detalles Bibliográficos
Autores principales: ‘t Hart, Leen M., Fritsche, Andreas, Nijpels, Giel, van Leeuwen, Nienke, Donnelly, Louise A., Dekker, Jacqueline M., Alssema, Marjan, Fadista, Joao, Carlotti, Françoise, Gjesing, Anette P., Palmer, Colin N.A., van Haeften, Timon W., Herzberg-Schäfer, Silke A., Simonis-Bik, Annemarie M.C., Houwing-Duistermaat, Jeanine J., Helmer, Quinta, Deelen, Joris, Guigas, Bruno, Hansen, Torben, Machicao, Fausto, Willemsen, Gonneke, Heine, Robert J., Kramer, Mark H.H., Holst, Jens J., de Koning, Eelco J.P., Häring, Hans-Ulrich, Pedersen, Oluf, Groop, Leif, de Geus, Eco J.C., Slagboom, P. Eline, Boomsma, Dorret I., Eekhoff, Elisabeth M.W., Pearson, Ewan R., Diamant, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749354/
https://www.ncbi.nlm.nih.gov/pubmed/23674605
http://dx.doi.org/10.2337/db13-0227

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