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DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy

Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. We screened DNA aptamer directed against AGEs (AGEs-aptamer) in vitro and examined its effects on renal injury in KKAy/Ta mice, an animal model of type 2 diabetes. Eight-week-old male KKAy/Ta or C57...

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Detalles Bibliográficos
Autores principales:	Kaida, Yusuke, Fukami, Kei, Matsui, Takanori, Higashimoto, Yuichiro, Nishino, Yuri, Obara, Nana, Nakayama, Yosuke, Ando, Ryotaro, Toyonaga, Maki, Ueda, Seiji, Takeuchi, Masayoshi, Inoue, Hiroyoshi, Okuda, Seiya, Yamagishi, Sho-ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749365/ https://www.ncbi.nlm.nih.gov/pubmed/23630304 http://dx.doi.org/10.2337/db12-1608

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