Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model

The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly ef...

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Detalles Bibliográficos
Autores principales: Yang, Byung-Keun, Hwang, Seung-Lark, Yun, Ik-Jin, Do, Eun-Ju, Lee, Won-Ha, Jung, Young-Mi, Hong, Sung-Chang, Park, Dong-Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Mycology 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749402/
https://www.ncbi.nlm.nih.gov/pubmed/23983521
http://dx.doi.org/10.4489/MYCO.2009.37.2.128
Descripción
Sumario:The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 µg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.

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