Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model

The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly ef...

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Autores principales: Yang, Byung-Keun, Hwang, Seung-Lark, Yun, Ik-Jin, Do, Eun-Ju, Lee, Won-Ha, Jung, Young-Mi, Hong, Sung-Chang, Park, Dong-Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Mycology 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749402/
https://www.ncbi.nlm.nih.gov/pubmed/23983521
http://dx.doi.org/10.4489/MYCO.2009.37.2.128
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author Yang, Byung-Keun
Hwang, Seung-Lark
Yun, Ik-Jin
Do, Eun-Ju
Lee, Won-Ha
Jung, Young-Mi
Hong, Sung-Chang
Park, Dong-Chan
author_facet Yang, Byung-Keun
Hwang, Seung-Lark
Yun, Ik-Jin
Do, Eun-Ju
Lee, Won-Ha
Jung, Young-Mi
Hong, Sung-Chang
Park, Dong-Chan
author_sort Yang, Byung-Keun
collection PubMed
description The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 µg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
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spelling pubmed-37494022013-08-27 Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model Yang, Byung-Keun Hwang, Seung-Lark Yun, Ik-Jin Do, Eun-Ju Lee, Won-Ha Jung, Young-Mi Hong, Sung-Chang Park, Dong-Chan Mycobiology Research Article The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 µg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action. The Korean Society of Mycology 2009-06 2009-06-30 /pmc/articles/PMC3749402/ /pubmed/23983521 http://dx.doi.org/10.4489/MYCO.2009.37.2.128 Text en Copyright © 2009 The Korean Society of Mycology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Byung-Keun
Hwang, Seung-Lark
Yun, Ik-Jin
Do, Eun-Ju
Lee, Won-Ha
Jung, Young-Mi
Hong, Sung-Chang
Park, Dong-Chan
Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
title Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
title_full Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
title_fullStr Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
title_full_unstemmed Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
title_short Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
title_sort antitumor effects and immunomodulating activities of phellinus linteus extract in a ct-26 cell-injected colon cancer mouse model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749402/
https://www.ncbi.nlm.nih.gov/pubmed/23983521
http://dx.doi.org/10.4489/MYCO.2009.37.2.128
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