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A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism

Sarcoidosis is a chronic multisystemic inflammatory disease of unknown etiology, which is characterized by noncaseating granulomatous inflammation of the involved organs. It is known that neurosarcoidosis involving the nervous system occurs in about 5% of patients with sarcoidosis. However, neurosar...

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Autores principales: Hwang, Jin Kyung, Cho, Joo Hee, Park, So Young, Son, Jung Il, Jo, Uk, Chin, Sang Ouk, Lee, Yun Jung, Choi, Moon Chan, Rhee, Sang Youl, Kim, Eui Jong, Chon, Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749535/
https://www.ncbi.nlm.nih.gov/pubmed/23991342
http://dx.doi.org/10.1155/2013/816236
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author Hwang, Jin Kyung
Cho, Joo Hee
Park, So Young
Son, Jung Il
Jo, Uk
Chin, Sang Ouk
Lee, Yun Jung
Choi, Moon Chan
Rhee, Sang Youl
Kim, Eui Jong
Chon, Suk
author_facet Hwang, Jin Kyung
Cho, Joo Hee
Park, So Young
Son, Jung Il
Jo, Uk
Chin, Sang Ouk
Lee, Yun Jung
Choi, Moon Chan
Rhee, Sang Youl
Kim, Eui Jong
Chon, Suk
author_sort Hwang, Jin Kyung
collection PubMed
description Sarcoidosis is a chronic multisystemic inflammatory disease of unknown etiology, which is characterized by noncaseating granulomatous inflammation of the involved organs. It is known that neurosarcoidosis involving the nervous system occurs in about 5% of patients with sarcoidosis. However, neurosarcoidosis without systemic involvement is extremely rare. We present a case of suspicious neurosarcoidosis affecting the pituitary gland, which was manifested as chronic uncontrolled headache, panhypopituitarism, central diabetes insipidus, and hypercalcemia. Though the biopsy at the pituitary lesion was not performed due to the high risk of surgical complication, treatment was needed urgently and we started steroid therapy. After steroid therapy, we observed the immediate symptom relief with improved hypercalcemia. According to the follow-up examination, no recurrent symptom was seen, and resolution of the pituitary lesion with improving panhypopituitarism was noted.
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spelling pubmed-37495352013-08-29 A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism Hwang, Jin Kyung Cho, Joo Hee Park, So Young Son, Jung Il Jo, Uk Chin, Sang Ouk Lee, Yun Jung Choi, Moon Chan Rhee, Sang Youl Kim, Eui Jong Chon, Suk Case Rep Endocrinol Case Report Sarcoidosis is a chronic multisystemic inflammatory disease of unknown etiology, which is characterized by noncaseating granulomatous inflammation of the involved organs. It is known that neurosarcoidosis involving the nervous system occurs in about 5% of patients with sarcoidosis. However, neurosarcoidosis without systemic involvement is extremely rare. We present a case of suspicious neurosarcoidosis affecting the pituitary gland, which was manifested as chronic uncontrolled headache, panhypopituitarism, central diabetes insipidus, and hypercalcemia. Though the biopsy at the pituitary lesion was not performed due to the high risk of surgical complication, treatment was needed urgently and we started steroid therapy. After steroid therapy, we observed the immediate symptom relief with improved hypercalcemia. According to the follow-up examination, no recurrent symptom was seen, and resolution of the pituitary lesion with improving panhypopituitarism was noted. Hindawi Publishing Corporation 2013 2013-08-07 /pmc/articles/PMC3749535/ /pubmed/23991342 http://dx.doi.org/10.1155/2013/816236 Text en Copyright © 2013 Jin Kyung Hwang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hwang, Jin Kyung
Cho, Joo Hee
Park, So Young
Son, Jung Il
Jo, Uk
Chin, Sang Ouk
Lee, Yun Jung
Choi, Moon Chan
Rhee, Sang Youl
Kim, Eui Jong
Chon, Suk
A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
title A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
title_full A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
title_fullStr A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
title_full_unstemmed A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
title_short A Case of Possible Neurosarcoidosis Presenting as Intractable Headache and Panhypopituitarism
title_sort case of possible neurosarcoidosis presenting as intractable headache and panhypopituitarism
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749535/
https://www.ncbi.nlm.nih.gov/pubmed/23991342
http://dx.doi.org/10.1155/2013/816236
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