HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level

Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of...

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Detalles Bibliográficos
Autores principales: Ayub, Ambreen, Ashfaq, Usman Ali, Haque, Asma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749539/
https://www.ncbi.nlm.nih.gov/pubmed/23991421
http://dx.doi.org/10.1155/2013/810461
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author Ayub, Ambreen
Ashfaq, Usman Ali
Haque, Asma
author_facet Ayub, Ambreen
Ashfaq, Usman Ali
Haque, Asma
author_sort Ayub, Ambreen
collection PubMed
description Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of transactivator protein HBxAg that may deregulate many pathways involving in metabolism of cells. Several monogenic and polygenic risk factors are also involved in HCC development. This review summarizes the mechanism involved in HCC development and discusses some promising therapies to make HCC curative.
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spelling pubmed-37495392013-08-29 HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level Ayub, Ambreen Ashfaq, Usman Ali Haque, Asma Biomed Res Int Review Article Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of transactivator protein HBxAg that may deregulate many pathways involving in metabolism of cells. Several monogenic and polygenic risk factors are also involved in HCC development. This review summarizes the mechanism involved in HCC development and discusses some promising therapies to make HCC curative. Hindawi Publishing Corporation 2013 2013-08-07 /pmc/articles/PMC3749539/ /pubmed/23991421 http://dx.doi.org/10.1155/2013/810461 Text en Copyright © 2013 Ambreen Ayub et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ayub, Ambreen
Ashfaq, Usman Ali
Haque, Asma
HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_full HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_fullStr HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_full_unstemmed HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_short HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_sort hbv induced hcc: major risk factors from genetic to molecular level
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749539/
https://www.ncbi.nlm.nih.gov/pubmed/23991421
http://dx.doi.org/10.1155/2013/810461
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